Table 2 Goat and sheep TSE isolate transmission into TgGoat-ARQ and TgBov mice.
From: Classical scrapie in small ruminants is caused by at least four different prion strains
TSE isolate | TgGoat-ARQ | TgBov | |||||||
|---|---|---|---|---|---|---|---|---|---|
Species | ID | 1st passage [45] | 2nd passage | 1st passage [45] | 2nd passage | ||||
MST ± SDa (n/n0)b | PrPres signature | MST ± SDa (n/n0)b | PrPres signature | MST ± SDa (n/n0)b | PrPres signature | MST ± SDa (n/n0)b | PrPres signature | ||
Goat | I2 | 526 ± 123 (6/6)c | 21 kDa | 555 ± 33 (4/4) | 21 kDa | 453 (1/6) | 21 kDa | 167 ± 9 (7/7) | 21 kDa |
I3 | 644 ± 14 (4/4) | > 650 (5/5) | 464 (1/7) | 163 ± 16 (7/7) | |||||
I9 | 578 ± 25 (5/5) | 547 ± 25 (6/6) | 324 ± 90 (6/6) | 174 ± 8 (5/5) | |||||
Sheep | 198/9 | 592 ± 13 (6/6) | 536 ± 46 (5/5) | 259 ± 20 (3/6) | 165 ± 7 (7/7) | ||||
Goat | F16 | 431 ± 22 (3/3) | 242 ± 26 (5/5) | 348 ± 58 (3/6) | 177 ± 9 (6/6) | ||||
F2 | 239 ± 21 (4/4) | 21 kDa | 212 ± 16 (6/6) | 21 kDa | 343 ± 163 (4/5) | 19 kDa | 198 ± 13 (6/6) | 19 kDa | |
F3 | 287 ± 14 (6/6) | 228 ± 7 (6/6) | 290 ± 48 (3/6) | 191 ± 3 (6/6) | |||||
F6 | 468 ± 15 (4/4) | 334 ± 6 (6/6) | 523 ± 166 (6/6) | 178 ± 13 (5/5) | |||||
N3-fast | 451 ± 9 (4/4) | 254 ± 50 (6/6) | 324d, > 650e (2/6) | 203 ± 5 (5/5)d | |||||
S2 | 228 ± 15 (6/6) | 233 ± 4 (6/6) | 384 ± 149 (6/6) | 237 ± 39 (9/9) | |||||
S3 | 221 ± 16 (6/6) | 233 ± 64 (5/5)c | 271 ± 19 (6/6) | 254 ± 52 (4/4) | |||||
Sheep | PS21 | 194 ± 5 (6/6) | 205 ± 18 (6/6) | 244 ± 3 (6/6) | 244 ± 3 (6/6) | ||||
Langlade | > 650 (3/3) | 500 ± 23 (4/4) | 491 ± 17 (4/6) | 229 ± 37 (4/4) | |||||
PS09 | 277 ± 31 (5/5) | NAf | 230 ± 66 (4/6) | 168 ± 6 (6/6) | |||||
Goat | UKA2 | 245 ± 36 (5/5) | 21 + 19 kDa | 252 ± 8 (6/6) | 21 + 19 kDa | 255 ± 69 (5/5) | 19 kDa | 187 ± 6 (6/6) | 19 kDa |
UKB2 | 345 ± 19 (7/7) | 19 kDa | 214 ± 34 (7/7) | 19 kDa | 205 ± 12 (7/7) | 196 ± 5 (6/6) | |||
Sheep | 08-8309 | 215 ± 18 (7/7) | NAf | – | 193 ± 15 (6/6) | 168 ± 5 (7/7) | |||
08-27433 | 186 ± 9 (7/7) | 187 ± 8 (7/7) | NAf | – | |||||
CH1641 | 217 ± 14 (7/7) | 180 ± 3(6/6) | |||||||
Goat | G2 | > 650 (1/4) | 21 kDa | 470 ± 22 (7/7) | 21 kDa | 610 (1/6) | 19 kDa | 348 ± 85 (6/6) | 19 kDa |
G3 | 466 ± 35 (4/4) | 375 ± 25 (4/4) | > 650 (0/6) | – | > 650 (0/3) | – | |||
N1 | 437 ± 4 (4/4) | 339 ± 19 (5/5) | 649 ± 9 (3/3) | 19 kDa | 495 ± 48 (4/4) | 19 kDa | |||
N3-slow | 451 ± 9 (4/4) | 254 ± 50 (6/6) | 324, > 650 (2/6) | 493 ± 72 (6/6)e | |||||
C1 | 483 ± 15 (4/4) | 301 ± 10 (4/4) | 650 (2/2) | 371 ± 51 (6/6) | |||||
C2 | 475 ± 31 (5/5) | 324 ± 9 (4/4) | > 650 (2/6) | 387 ± 12 (3/3) | |||||
Sheep | PS83 | 302 ± 18 (6/6) | NAf | – | > 650 (1/10) | 542 ± 50 (5/5) | |||
Goat | gtBSE | 346 ± 16 (6/6) | BSE | 309 ± 19 (5/5) | BSE | 260 ± 14 (6/6) | BSE | 266 ± 17 (5/5) | BSE |