Figure 4
From: Classical scrapie in small ruminants is caused by at least four different prion strains
Histological analysis of goat TSE isolate transmission in TgGoat-ARQ mice. IHC for PrPSc was performed using the R468 polyclonal antibody. PET blotting was performed using the Sha31 monoclonal antibody. ITNR: Intraneuronal; ITGL: Intra-microglial and intra-astrocytic; PRTC: fine particulate; GLAS: extracellular glia-associated; COAL: Coalescing; LINR: Linear; PLAQ: plaques (vascular and non-vascular); CCtx: Cerebral cortex; Stri: Striatum; Hpp; Hippocampus; Thal: Thalamus; Hpth: Hypothalamus; Midb: Midbrain; CbCtx: Cerebellar cortex; PoMe: Pons/medulla oblongata.