Figure 2
From: Liver organoids in domestic animals: an expected promise for metabolic studies
Preliminary data with chicken liver organoïds derived from chicken embryonic stem cells (cESC). A cESC were induced into endoderm before being turned into hepatoblasts, but failed to be induced in more mature hepatocytes under present tested protocols. B the expression of different markers was detected by qRT-PCR and illustrates the loss of pluripotent marker (OCT4), the weak induction into endoderm (SOX17) and then the present failure to get more specific hepatic markers (FOXA2, HNF4, AFP) with the current conditions.