Figure 11

Transcriptome profiling and GO enrichment analysis of expressed genes in PAMs from PRRSV-NADC30 like-HNhx-infected pigs with or without mAb-PN9cx3 treatment. A Heatmap analysis of genes upregulated by PRRSV-NADC30 like-HNhx infection but that exhibited reversal of this upregulation in PAMs of piglets treated with mAb-PN9cx3 before and after infection. B Heatmap analysis of genes downregulated by PRRSV-NADC30-like HNhx infection but that exhibited reversal of this downregulation in PAMs of mAb-PN9cx3-treated-and-infected piglets. The expression levels are indicated using a colour key: blue corresponds to low-level expression, and red corresponds to high-level expression. The row order reflects the hierarchical clustering results, and the values are scaled in the row direction. C Gene ontology (GO) enrichment analysis of genes upregulated by PRRSV-NADC30-like HNhx infection but that exhibited reversal of this upregulation in PAMs of piglets treated with mAb-PN9cx3 before and after infection. D Gene ontology (GO) enrichment analysis of genes downregulated by PRRSV-NADC30-like HNhx infection but that exhibited reversal of this downregulation in PAMs of piglets treated with mAb-PN9cx3 before and after infection.