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Figure 10 | Veterinary Research

Figure 10

From: A broadly neutralizing monoclonal antibody induces broad protection against heterogeneous PRRSV strains in piglets

Figure 10

Transcriptome profiling and gene ontology (GO) enrichment analyses of PAMs from PRRSV-JXA1-infected pigs with or without mAb-PN9cx3 treatment. A Heatmap analysis of genes upregulated by PRRSV-JXA1 in infected PAMs but that exhibited reversal of this upregulation in piglets treated with mAb-PN9cx3 before and after infection. B Heatmap analysis showing genes downregulated by PRRSV-JXA1 in infected PAMs but that exhibited reversal of this downregulation in piglets treated with mAb-PN9cx3 before and after infection. The expression levels are indicated by the colour key: blue corresponds to low-level expression, and red corresponds to high-level expression. The row order reflects the hierarchical clustering results, and the values are scaled in the row direction. C Gene ontology (GO) enrichment analysis of genes upregulated in PAMs induced with PRRSV-JXA1 but that exhibited reversal of this upregulation in piglets treated with mAb-PN9cx3 before and after infection.

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Veterinary Research

ISSN: 1297-9716