Figure 8

Bacterial invasion of epithelial cells pathway (KEGG ID:hsa05100) in the CoPS vs. H comparison. One of the most important pathways enriched by the differentially-expressed miRNAs. The green frame represents pathway-engaged genes. The target genes identified by the differential expression of miRNAs are marked yellow (included in one pathway) or orange (included in more than one pathway). Black arrows denote a molecular interaction or relation; dotted arrows represent an indirect link or unknown reaction. CDH1—E-Cadherin (Epithelial), CTNNB₁—Catenin Beta 1, CTNNA₁—Catenin Alpha 1, ARHGAP—GEM Interacting Protein, MET—MET Proto-Oncogene, Gab1—GRB2 Associated Binding Protein 1, CRK—CRK Proto-Oncogene, PIK3R1—Phosphoinositide-3-Kinase Regulatory Subunit 1, DOCK1—Dedicator Of Cytokinesis 1, CDC42—Cell Division Cycle 42, WASL—WASP Like Actin Nucleation Promoting Factor, RAC1—Rac Family Small GTPase 1, WASF2—WASP Family Member 2, ARPC1A—Actin Related Protein 2/3 Complex Subunit 1A, ACTG1—Actin Gamma 1, SEPT9—Septin 9, CBL—Cbl Proto-Oncogene, SHC1—SHC Adaptor Protein 1, CD2AP—CD2 Associated Protein, DNM2—Dynamin 2, CLTA—Clathrin Light Chain A, CAV2—Caveolin 2, CTTN—Cortactin, Src—SRC Proto-Oncogene, PTK2—Protein Tyrosine Kinase 2, Paxilin—PXN, FN1—Fibronectin 1, ITGA5—Integrin Subunit Alpha 5, ILK—Integrin Linked Kinase, CDC42—Cell Division Cycle 42, WASL—WASP Like Actin Nucleation Promoting Factor, RAC1—Rac Family Small GTPase 1, WASF2—WASP Family Member 2, ARHGEF2—Rho/Rac Guanine Nucleotide Exchange Factor 2, RhoG—Ras Homolog Family Member G, ELMO1—Engulfment And Cell Motility 1, DOCK1—Dedicator Of Cytokinesis 1, CRK—CRK Proto-Oncogene, MAD2L2—Mitotic Arrest Deficient 2 Like 2, RHOA—Ras Homolog Family Member A, ARPC1A—Actin Related Protein 2/3 Complex Subunit 1A, ACTG1—Actin Gamma 1, VCL—Vinculin.