Evaluating a tylosin dosage regimen for treatment of Staphylococcus delphini infection in mink (Neovison vison): a pharmacokinetic-pharmacodynamic approach

Table 4 Calculated PK/PD targets for a bacteriostatic and bactericidal effect, respectively, of TYL against S. delphini

	fAUC_po,0–24 h/MIC (h)		(fAUC_po,0–24 h/MIC)/24 Scalar		fT > MIC (h)		fT > MIC (%)
	B_static	B_cidal	B_static	B_cidal	B_static	B_cidal	B_cidal
Average	48.91 (± 0.3)	98.72 (± 0.9)	2.04 (± 0.01)	4.11 (± 0.04)	10.30 (± 0.04)	13.20 (± 0.06)	55 (± 0.26)

The value for fAUC _po,0–24/MIC (h) presents the required area under the concentration–time curve of TYL over MIC, and fT > MIC (%) is the required duration of serum concentration of TYL above MIC. The PKPD targets were obtained (mean ± SE from an I_max sigmoidal model for predicted bacteriostatic and bactericidal effects corresponding to no change and one Log₁₀ reduction, respectively, of initial bacterial concentration after 24 h. Scalar fAUC/MIC was obtained by dividing the AUC/MIC cutoff by 24 h.

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