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Table 2 Population primary and secondary parameters of TYL estimated with a two-compartment model by fitting IV and oral PK data simultaneously

From: Evaluating a tylosin dosage regimen for treatment of Staphylococcus delphini infection in mink (Neovison vison): a pharmacokinetic-pharmacodynamic approach

 

Parameter

Units

IV and oral

TV

SE

Primary parameters

Ka

1/h

0.23

0.023

V1

L/kg

2.24

1.076

V2

L/kg

1.33

0.523

CL

L/h/kg

3.41

0.756

Q

L/h/kg

1.97

1.453

F

 

0.41

0.150

MultiSD

Scalar

0.15

0.114

SD IV

µg/mL

0.020

0.007

SD Oral

µg/mL

0.006

0.006

BSV V1 (CV%)

21.21

0.079

BSV CL (CV%)

10.00

0.161

η shrinkage V1

0.12

 

η shrinkage CL

0.20

 

Secondary parameters

AUCIV

µg h/mL

3.05

0.565

AUCOral

µg h/mL

1.18

0.195

Ka HL

h

3.00

0.319

Tmax

h

1.75

0.138

Cmax

µg/mL

0.43

0.072

  1. Ka is the absorption rate constant, V1 and V2 are volumes of distribution in central and peripheral compartments, respectively, CL is body clearance, Q is inter-compartment clearance, MultiSD is multiplicative error term and it should be interpreted as a coefficient of variation, (here of 15%), SD is the additive component of the error term, BSV is between subject variability expressed as CV, Shrinkage refers to the quality of the estimated BSV. For the present study, an η-shrinkage lower than 0.4 has been considered as acceptable. AUCIV and AUCOral are area under the concentration–time curve after IV and oral dosing, respectively and Ka-HL is half-life of absorption. TV is the population typical value. The precision of parameters (SE) was computed by the bootstrap tool in Phoenix®.
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Veterinary Research

ISSN: 1297-9716