Figure 6

Visual Predictive Check (VPC) plots of observed serum concentration (µg/mL) of TYL vs. time (h) and observed and predicted quantiles. The VPC diagnostic plots illustrate the trends with the observed 50% quantiles (red line) and predictive check 50% quantile (black line) that were computed using Monte Carlo simulation over the observed serum concentrations (blue spots) following IV (left) and oral (right) administration. The blue shaded area corresponds to the 95% confidence interval of the 50% simulated quantile (black line).