|
Parameter
|
Mean
|
|---|
|
Emax (log cfu/mL)
|
4.39
|
|
E0 (log cfu/mL)
|
−6.3
|
|
Emax—E0 (log cfu/mL)
|
10.69
|
|
EC50 (log cfu/mL)
|
119.31
|
|
AUC24h/MIC for bacteriostatic activity (h)
|
113.11
|
|
AUC24h/MIC for bactericidal activity (h)
|
143.14
|
|
AUC24h/MIC for bacterial elimination (h)
|
159.16
|
|
Slope (N)
|
5.02
|
- Emax, difference in number of bacteria (cfu/mL) in blank serum sample between time 0 and 24 h; E0, difference in number of bacteria (cfu/mL) in pooled serum samples between time 0 and 24 h when the detection limit (20 cfu/mL) is reached; EC50, pharmacokinetic–pharmacodynamic parameter of drug that produced 50% of the maximal antibacterial effect; AUC24h/MIC, values required to achieve bacteriostatic, bactericidal and bacterial elimination activity; slope (N), the Hill coefficient that describes the steepness of the curve
