Skip to main content

Table 6 Pharmacokinetic–pharmacodynamic integration of ex vivo data after IM administration of cefquinome (1 mg/kg)

From: Pharmacokinetic and pharmacodynamic integration for optimal dosage of cefquinome against Streptococcus equi subsp. equi in foals

Parameter

Mean

Emax (log cfu/mL)

4.39

E0 (log cfu/mL)

−6.3

Emax—E0 (log cfu/mL)

10.69

EC50 (log cfu/mL)

119.31

AUC24h/MIC for bacteriostatic activity (h)

113.11

AUC24h/MIC for bactericidal activity (h)

143.14

AUC24h/MIC for bacterial elimination (h)

159.16

Slope (N)

5.02

  1. Emax, difference in number of bacteria (cfu/mL) in blank serum sample between time 0 and 24 h; E0, difference in number of bacteria (cfu/mL) in pooled serum samples between time 0 and 24 h when the detection limit (20 cfu/mL) is reached; EC50, pharmacokinetic–pharmacodynamic parameter of drug that produced 50% of the maximal antibacterial effect; AUC24h/MIC, values required to achieve bacteriostatic, bactericidal and bacterial elimination activity; slope (N), the Hill coefficient that describes the steepness of the curve
Back to article page

Veterinary Research

ISSN: 1297-9716