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Table 3 Mean pharmacokinetic values (± SD) of cefquinome after IV administration of 1 mg/kg in horses (n = 6) determined by high-performance liquid chromatography

From: Pharmacokinetic and pharmacodynamic integration for optimal dosage of cefquinome against Streptococcus equi subsp. equi in foals

Parameter Unit Mean
A μg/mL 55.89 ± 13.21
α 1/h 4.92 ± 1.59
α_HL H 0.16 ± .08
B μg/mL 1.25 ± .16
β 1/h .25 ± .04
β_HL H 2.77 ± .40
AUC μg·h/mL 15.15 ± 1.47
AUMC μg·h2/mL 21.82 ± 4.39
K12 1/h 1.44 ± .16
K21 1/h 0.37 ± .06
MRT H 1.43 ± .21
Vdss L/kg 0.09 ± .01
CLB L/h/kg 0.06 ± .01
  1. A and B zero-time serum concentration intercepts of biphasic IV disposition curves, α distribution rate constant, α_HL half-life of distribution, β elimination rate constant, β_HL half-life of elimination, AUC area under the curve, AUMC area under the first moment curve, K12 and K21 first-order transfer rate constants for drug distribution from the central compartment to the peripheral compartment and from the peripheral compartment to the central compartment, respectively, MRT mean residence time, Vdss volume of distribution at steady-state, CLB total body clearance