Figure 3

Effect of Deferiprone on survival of Oncorhynchus mykiss challenged with Piscirickettsia salmonis. The data show the survival percentage of fish subjected to two concentrations of DFP in feed (50 and 100 mg/Kg per day; DFP 50 blue lines and DFP 100 gray lines, respectively) and two delivery methods: 10 days before challenge (BC, dotted line) and immediately after challenge (AC, continuous line). Survival was monitored on a daily basis for 30 days. Kaplan–Meier and subsequent survival curve comparison by Log-rank test was performed. Asterisks show statistically significant differences between DFP treated and untreated (control black line) fish and denote: *p-value < 0.05, **p < 0.01, ****p < 0.0001. The horizontal light green line denotes the 50% of survival percentage and the vertical light red lines represent the sampling points (S0–S5) at different days post-challenge (dpc). The experiments were performed in duplicate tanks and representative data is shown.