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Table 1 Results of one-way PERMANOVA to detect differences in fecal community structure between pre-treatment (Pre), immediately post-treatment (Post), and four weeks post-treatment (4w post) samples collected from C57BL/6NHsd mice receiving the indicated treatments ( n= 12)

From: Acute and long-term effects of antibiotics commonly used in laboratory animal medicine on the fecal microbiota

Treatment

Similarity

Main effects

Pre vs post

Pre vs 4w post

p

F

p

F

p

F

TMS

Bray–Curtis

0.34

1.06

0.26

1.25

0.31

1.06

Jaccard

0.07

1.53

0.11

1.52

0.05

1.90

Enrofloxacin PO

Bray–Curtis

0.002

4.11

0.001

5.86

0.006

4.51

Jaccard

0.0001

15.95

0.0001

23.71

0.0001

20.56

Enrofloxacin IP

Bray–Curtis

0.004

3.36

0.01

4.03

0.07

2.40

Jaccard

0.0001

11.97

0.0001

16.69

0.0001

6.09

TAB

Bray–Curtis

0.0001

27.74

0.0001

40.20

0.0005

7.16

Jaccard

0.0001

20.58

0.0001

29.25

0.0001

14.23

Control

Bray–Curtis

0.35

1.06

0.44

0.87

0.30

1.09

Jaccard

0.04

1.81

0.08

1.84

0.15

1.39