Acute and long-term effects of antibiotics commonly used in laboratory animal medicine on the fecal microbiota

Table 1 Results of one-way PERMANOVA to detect differences in fecal community structure between pre-treatment (Pre), immediately post-treatment (Post), and four weeks post-treatment (4w post) samples collected from C57BL/6NHsd mice receiving the indicated treatments ( n = 12)

Treatment	Similarity	Main effects		Pre vs post		Pre vs 4w post
Treatment	Similarity	p	F	p	F	p	F
TMS	Bray–Curtis	0.34	1.06	0.26	1.25	0.31	1.06
TMS	Jaccard	0.07	1.53	0.11	1.52	0.05	1.90
Enrofloxacin PO	Bray–Curtis	0.002	4.11	0.001	5.86	0.006	4.51
Enrofloxacin PO	Jaccard	0.0001	15.95	0.0001	23.71	0.0001	20.56
Enrofloxacin IP	Bray–Curtis	0.004	3.36	0.01	4.03	0.07	2.40
Enrofloxacin IP	Jaccard	0.0001	11.97	0.0001	16.69	0.0001	6.09
TAB	Bray–Curtis	0.0001	27.74	0.0001	40.20	0.0005	7.16
TAB	Jaccard	0.0001	20.58	0.0001	29.25	0.0001	14.23
Control	Bray–Curtis	0.35	1.06	0.44	0.87	0.30	1.09
Control	Jaccard	0.04	1.81	0.08	1.84	0.15	1.39

ISSN: 1297-9716