Figure 1

T. spiralis larval burden increased in mice lacking NLRP3 but not Caspase 1/11 or ASC. WT and NLRP3^−/− mice were infected with 300 ML. Muscle larvae were recovered at 35 dpi from WT and NLRP3^−/− mice and calculated. The symbols represent individual animals, and horizontal lines indicate the medians. The data shown are representative of three independent experiments. *p < 0.05, **p < 0.01 and ***p < 0.001 vs WT mice (n = 10) as indicated by the line (Dunnett’s multiple comparison following ANOVA). No significance is marked as ns.