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Table 2 Most highly differentially expressed pathways comparing zero and eight hours post Salmonella infection in primary porcine neutrophils

From: Salmonella enterica serovar Typhimurium inhibits the innate immune response and promotes apoptosis in a ribosomal/TRP53-dependent manner in swine neutrophils

Pathway name

Change direction

Pathway genes count

Pathway p-value

MicroRNA (miRNA) biogenesis

Up

5

1.54E−04

Propanoate metabolism

Up

6

4.63E−04

Pyruvate metabolism

Up

7

6.62E−04

Double stranded RNA induced gene expression

Up

4

0.001261

Huntington's disease

Up

15

0.001402

Direct p53 effectors

Up

12

0.001602

Nucleotide Excision Repair

Up

8

0.001777

Pyruvate metabolism

Up

6

0.002333

Regulatory RNA pathways

Up

7

0.002367

mRNA Splicing

Up

12

0.002379

mRNA Splicing—Major Pathway

Up

12

0.002379

Purine catabolism

Up

3

0.002959

Cleavage of Growing Transcript in the Termination Region

Up

6

0.003025

RNA Polymerase II Transcription Termination

Up

6

0.003025

Processing of Capped Intron-Containing PrE−mRNA

Up

12

0.003051

Atm signaling pathway

Up

4

0.003385

RNA Polymerase II Transcription

Up

11

0.003468

HIV Infection

Up

18

0.003569

Pyrimidine metabolism

Up

9

0.004232

Inhibition of TSC complex formation by PKB

Up

2

0.004779

Ribosome

Down

12

3.01E−05

Cytokine-cytokine receptor interaction

Down

14

9.58E−05

Interferon alpha/beta signaling

Down

6

1.10E−04

Eukaryotic Translation Termination

Down

9

3.07E−04

Peptide chain elongation

Down

9

3.07E−04

Viral mRNA Translation

Down

9

3.55E−04

Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)

Down

9

4.67E−04

Eukaryotic Translation Elongation

Down

9

4.67E−04

L13a-mediated translational silencing of Ceruloplasmin expression

Down

10

5.85E−04

GTP hydrolysis and joining of the 60S ribosomal subunit

Down

10

6.55E−04

Formation of a pool of free 40S subunits

Down

9

9.93E−04

Cap-dependent Translation Initiation

Down

10

0.001121

Eukaryotic Translation Initiation

Down

10

0.001121

Class A/1 (Rhodopsin-like receptors)

Down

16

0.00113

Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Down

9

0.001556

Nonsense-Mediated Decay (NMD)

Down

9

0.001556

Acyl chain remodelling of PI

Down

2

0.001704

Acyl chain remodelling of PS

Down

2

0.001704

Binding and entry of HIV virion

Down

2

0.001704

SRP-dependent cotranslational protein targeting to membrane

Down

9

0.002351

Influenza Viral RNA Transcription and Replication

Down

9

0.002855

Signaling by GPCR

Down

24

0.004493

Influenza Life Cycle

Down

9

0.004493

Influenza Infection

Down

9

0.004895

Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha

Down

2

0.004973