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Table 1 Presence and distribution of matrix metalloproteinases (MMPs), inhibitory factors of metalloproteinases (TIMPs) and some components of the extracellular matrix (ECM) in placental samples obtained from an experimental infection model in pregnant cattle

From: Crosstalk between Neospora caninum and the bovine host at the maternal-foetal interface determines the outcome of infection

  Maternal stroma Caruncular epithelium Foetal mesenchyme Uninucleated trophoblast cells Binucleated trophoblast cells
10 dpi 20 dpi 10 dpi 20 dpi 10 dpi 20 dpi 10 dpi 20 dpi 10 dpi 20 dpi
MMP-2
 G-Control + + ++ ++ + +
 G-NcSpain7 + ++ ++ +++ + + ++
 G-NcSpain1H + + ++   + + +
MMP-14
 G-Control + + ++ ++ +
 G-NcSpain7 ++ + ++ ++++ +
 G-NcSpain1H + + + + ++ ++ +
TIMP-2
 G-Control ++++ ++++
 G-NcSpain7 ++++ ++++*
 G-NcSpain1H ++++ ++++
Fibronectin
 G-Control + + ++ ++ ++ ++
 G-NcSpain7 + +/−* ++ +/−* + +/− *
 G-NcSpain1H ++ + +++ ++ ++ ++
Vimentin
 G-Control +++ +++ ++ ++
 G-NcSpain7 +++ +++/− * ++ ++/− *
 G-NcSpain1H +++ +++ ++ ++
Collagen IV
 G-Control + + ++++ ++++
 G-NcSpain7 + +/− * ++++ ++++/−*
 G-NcSpain1H + + ++++ ++++
  1. − no immunolabeling (total absence of immunoreactive cells); + low immunolabeling; ++ moderate immunolabeling; +++ high immunolabeling; and ++++ extremely high immunolabeling
  2. *Loss of staining in necrotic/damaged areas