Table 1 Presence and distribution of matrix metalloproteinases (MMPs), inhibitory factors of metalloproteinases (TIMPs) and some components of the extracellular matrix (ECM) in placental samples obtained from an experimental infection model in pregnant cattle
Maternal stroma | Caruncular epithelium | Foetal mesenchyme | Uninucleated trophoblast cells | Binucleated trophoblast cells | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
10 dpi | 20 dpi | 10 dpi | 20 dpi | 10 dpi | 20 dpi | 10 dpi | 20 dpi | 10 dpi | 20 dpi | |
MMP-2 | ||||||||||
G-Control | + | + | ++ | ++ | – | – | + | + | – | – |
G-NcSpain7 | + | ++ | ++ | +++ | – | + | + | ++ | – | – |
G-NcSpain1H | + | + | ++ | – | + | + | + | – | – | |
MMP-14 | ||||||||||
G-Control | – | + | – | + | ++ | ++ | – | + | – | – |
G-NcSpain7 | – | ++ | – | + | ++ | ++++ | – | + | – | – |
G-NcSpain1H | + | + | + | + | ++ | ++ | – | + | – | – |
TIMP-2 | ||||||||||
G-Control | – | – | – | – | – | – | – | – | ++++ | ++++ |
G-NcSpain7 | – | – | – | – | – | – | – | – | ++++ | ++++* |
G-NcSpain1H | – | – | – | – | – | – | – | – | ++++ | ++++ |
Fibronectin | ||||||||||
G-Control | + | + | – | – | ++ | ++ | – | – | ++ | ++ |
G-NcSpain7 | + | +/−* | – | – | ++ | +/−* | – | – | + | +/− * |
G-NcSpain1H | ++ | + | – | – | +++ | ++ | – | – | ++ | ++ |
Vimentin | ||||||||||
G-Control | +++ | +++ | – | – | ++ | ++ | – | – | – | – |
G-NcSpain7 | +++ | +++/− * | – | – | ++ | ++/− * | – | – | – | – |
G-NcSpain1H | +++ | +++ | – | – | ++ | ++ | – | – | – | – |
Collagen IV | ||||||||||
G-Control | + | + | – | – | ++++ | ++++ | – | – | – | – |
G-NcSpain7 | + | +/− * | – | – | ++++ | ++++/−* | – | – | – | – |
G-NcSpain1H | + | + | – | – | ++++ | ++++ | – | – | – | – |