Figure  8

Comparison of PRRs, cytokine, chemokine, endothelial adhesion molecule, MMP and TIMP transcript expression between animals carrying NVFs and VFs from the G-NcSpain7 group. Scatter-plot graphs of relative mRNA expression levels (as the fold change) of PRRs, pro- and anti-inflammatory/regulatory cytokines, chemokines, endothelial adhesion molecules, MMPs and TIMPs that were differentially expressed between animals carrying NVFs and VFs in the CA (A) and CO (B) collected at 20 dpi from cows experimentally infected with Nc-Spain7 at 110 days of gestation. Data are presented as individual points. Horizontal lines represent median values for each group. ****, ***, ** and * indicate P < 0.0001, P < 0.001, P < 0.01 and P < 0.05 significant differences, respectively, and σ indicates P < 0.1. The δ symbol indicates lower expression compared to that in the uninfected control group. Three randomly selected medial caruncles and cotyledons from each animal were analysed.