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Figure 3 | Veterinary Research

Figure 3

From: Unexpected high frequency of neurofibroma in the celiac ganglion of German cattle

Figure 3

Neurofibroma in the bovine celiac ganglion. Myxoid parts with comparatively few cells in bovine neurofibroma of the celiac ganglion can be distinguished at 40 × magnification (A Hematoxylin/Eosin). A loss of structure with two types of dominating cell populations can be seen at 400x magnification: (1) small elongated nuclei with condensed chromatin (Schwann cells, black arrows) and (2) large rather ovoid nuclei with coarse chromatin (fibroblasts, white arrows) (B). Elastica-van-Gieson staining reveals teared-looking collagen fibres reminiscient of “shredded carrots” (C) while Gomori staining shows tattered remains of the endoneuria basal membranes of Schwann cells. Schwann cells in the tumor are positive for S100 (E), Vimentin (F) and at a low level GFAP (G). Few axons positive for Neurofilament (J) and PGP9.5 (I) are visible and occasionally MPB-positive ones (H). Schwann cells express Neurofibromin 1 and 2 in their nuclei (K, L). bar = 50 µm.

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