Characterization of splenic MRC1hiMHCIIlo and MRC1loMHCIIhi cells from the monocyte/macrophage lineage of White Leghorn chickens

Table 2 Phenotypic and functional characteristics of splenic MRC1^loMHCII^hiand MRC1^hiMHCII^lomonocyte/macrophage lineage cells during steady state and inflammatory conditions

Characteristics	MRC1^loMHCII^hi	MRC1^hiMHCII^lo
Phenotype	High MHCII, MHCI, CD80	High MRC1
Macrophages signature genes*	↑↑	↑
Phagocytosis	↑	↑↑
Migration	↑	↑↑
Proportion	Decreased	Increased
Phenotype change	Decreased MRC1	Increased granularity Decreased MHCII
Cytokines	↑↑	↑
Bactericidal activity	↑	↑↑

The last four lines represent the characteristics of splenic MRC1^loMHCII^hi and MRC1^hiMHCII^lo cells during LPS-induced inflammation.

ISSN: 1297-9716