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Figure 2 | Veterinary Research

Figure 2

From: Distinct transcriptome signatures of Helicobacter suis and Helicobacter heilmannii strains upon adherence to human gastric epithelial cells

Figure 2Figure 2

Fold change data of up- and down-regulated genes of MKN7-boundH. suisandH. heilmannii(i.e. cases) compared to unboundH. suisandH. heilmannii(i.e. controls). A Up-regulated H. suis genes. B Down-regulated H. suis genes. C Up-regulated H. heilmannii genes. D Down-regulated H. heilmannii genes. A, B Fold change data of up- (A) and down-regulated (B) H. suis genes (hypothetical protein genes excluded, except for H. suis 104628.16_00458) (with padj ≤ 0.01; fold change ≥ 2). A The up-regulation of 50 H. suis genes (33 hypothetical protein genes excluded) ranged from 2.01- to 3.89-fold. B The down-regulation of 42 H. suis genes (9 hypothetical protein genes excluded) ranged from 2.0- to 3.76-fold. C, D Fold change data of up- (C) and down-regulated (D) H. heilmannii genes (hypothetical protein genes excluded) (with padj ≤ 0.01; fold change ≥ 2). C The up-regulation of 43 H. heilmannii genes (17 hypothetical protein genes excluded) ranged from 2- to 4.64-fold. D The down-regulation of 54 genes (29 hypothetical protein genes excluded) ranged from 2.02- to 5.26-fold. Common up- or down-regulated genes in both MKN7-bound H. suis and H. heilmannii according to the reciprocal BLASTp analysis are displayed in orange. Interesting genes probably associated with virulence and colonization capacity are displayed in blue. 16U: general stress protein 16U gene; FlgA: flagellar basal body P-ring biosynthesis protein gene; FliW: flagellar assembly factor FliW gene; ggt: gamma-glutamyl transpeptidase gene; GrpE: heat shock protein GrpE gene; MACP4: methyl-accepting chemotaxis protein 4 gene; NikB: nickel transport system permease protein gene; omp: outer membrane protein gene; PctC: methyl-accepting chemotaxis protein PctC gene; ppi: peptidyl-prolyl cis,trans-isomerase gene; RecA: recombinase A gene; SPFM: secreted protein involved in flagellar motility gene; TerD: tellurium resistance gene; Tipα: tumor necrosis factor-α inducing protein gene; UreB: urease subunit beta gene; UreF: urease accessory protein UreF gene; UreH: urease accessory protein UreH gene; YlqC: KH domain RNA binding protein gene.

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