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Table 3 Top 25 up- and down-regulated DEGs in the brain at 24 and 72 hpi.

From: RNA-Seq analysis of European sea bass (Dicentrarchus labrax L.) infected with nodavirus reveals powerful modulation of the stress response

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Blast2GO UniProt/SwissProt description FC Blast2GO UniProt/SwissProt description FC
24 hpi
 Hydroxytryptamine receptor 3E (5HT3E5) 51.82    Prolactin (PRL) −101144.45
 Bile acid-CoA:amino acid N-acyltransferase (BAAT) 13.07    Somatolactin (SL) −13670.06
 Actin-related protein 2/3 complex subunit 1A(ARC1A) 12.76    Somatotropin (SOMA)–growht hormone (GH) −2711.84
 Collagen alpha-1(X) chain (COAA1) 10.87    Gonadotropin subunit beta-2 (GTHB2) −1896.99
 B2 bradykinin receptor (BKRB2) 7.36    O-acyltransferase like protein (OACYL) −377.22
 Deoxyribonuclease-1 (DNAS1) 6.95    Pro-opiomelanocortin (POMC) −349.84
 Deoxyribonuclease-1 (DNAS1) 6.48    Serotransferrin-1 (STF) −240.04
Alkaline phosphatase, tissue-nonspecific isozyme (PPBT) 6.20    Thyrotropin subunit beta (TSHB) −172.68
 Proline-rich basic protein 1 (PROB1) 4.78    Gonadotropin alpha chain (GLHA) −71.08
 Probable cysteine–tRNA ligase, mitochondrial (SYCM) 4.68    Transmembrane protein 130 (TM130) −27.42
 MAGUK p55 subfamily member 4 (MPP4) 4.34    LINE-1 type transposase domain-containing protein 1 (LITD1) −18.39
 Acidic repeat-containing protein (ACRC) 4.20    Pituitary-specific positive transcription factor 1 (PIT1) −16.88
 Gag-Pol polyprotein (POL) 4.14    Troponin T, fast skeletal muscle isoforms (TNNT3) −16.50
 MICAL-like protein 2 (MILK2) 4.12    Transcription factor COE1 (COE1) −16.04
 Leucine-rich repeat and coiled-coil domain-containing protein 1 (LRCC1) 4.07    Methylmalonyl-CoA mutase, mitochondrial (MUTA) −15.94
 Tetranectin (TETN) 3.86    Gonadotropin subunit beta-1 (GTHB1) −12.59
 ATP-binding cassette sub-family A member 1 (ABCA1) 3.81    LINE-1 reverse transcriptase homolog (LIN1) −10.49
 Oxysterol-binding protein-related protein 11 (OSB11) 3.78    Pituitary homeobox 3 (PITX3) −10.15
 DNA replication complex GINS protein PSF3 (PSF3) 3.58    Myosin regulatory light chain 2, skeletal muscle isoform type 2 (MLRS) −9.10
 Filamin-C (FLNC) 3.57    NLR family CARD domain containing 3 (NLRC3) −8.70
 Leukocyte cell-derived chemotaxin-2 (LECT2) 3.55    LINE-1 retrotransposable element ORF2 protein (LORF2) −8.66
 Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (SAMH1) 3.50    UPF0577 protein KIAA1324 (K1324) −8.58
 Protein largen (LARGN) 3.41    NADH dehydrogenase (NDUFA1) −7.48
 High affinity choline transporter 1 (SC5A7) 3.37    Regulator of rDNA transcription protein 15 (RRT15) −7.20
 Cathepsin D (CATD) 3.36    Fructose-bisphosphate aldolase A (ALDOA) −6.90
72 hpi
 Prolactin (PRL) 4713.60    Myosin regulatory light chain 2, skeletal muscle isoform type 2 (MLRS) −47.94
 Somatotropin (SOMA) 1332.49    Collagen alpha-1(II) chain (CO2A1) −34.45
 Thyrotropin subunit beta (TSHB) 27.90    Transposon Ty3-I Gag-Pol polyprotein (YI31B) −30.32
 Probable cysteine–tRNA ligase, mitochondrial (SYCM) 25.81    Fructose-bisphosphate aldolase A (ALDOA) −19.98
 Gonadotropin alpha chain (GLHA) 19.53    Troponin T, fast skeletal muscle isoforms (TNNT3) −18.43
 Pentraxin-4 (PTX4) 13.24    Sodium channel protein type 4 subunit alpha B (SC4AB) −14.00
 Pro-opiomelanocortin (POMC) 13.23    Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 (AT2A1) −13.68
 LINE-1 retrotransposable element ORF2 protein (LORF2) 10.99    Creatine kinase M-type (KCRM) −12.46
 Serine protease 48 (PRS48) 9.97    Actin, alpha skeletal muscle 2 (ACT2) −11.73
 Probable E3 ubiquitin-protein ligase HERC4 (HERC4) 8.55    Keratin, type I cytoskeletal 17 (K1C17) −11.31
 Sacsin (SACS) 7.07    Parvalbumin alpha (PRVA) −10.45
 C-X-C motif chemokine 9 (CXCL9) 7.07    Collagen alpha-1(II) chain (CO2A1) −9.10
 Radical S-adenosyl methionine domain-containing protein 2 (RSAD2) 6.63    Keratin, type I cytoskeletal 13 (K1C13) −8.06
 Sacsin (SACS) 6.37    DNA damage-inducible transcript 4-like protein (DDT4L) −5.60
 Receptor-transporting protein 3 (RTP3) 5.81    Receptor-type tyrosine-protein phosphatase F (PTPRF) −5.58
 Receptor-type tyrosine-protein phosphatase F (PTPRF) 5.75    Metabotropic glutamate receptor 8 (GRM8) −5.54
 Complement C3 (CO3) 5.66    Alpha-1B adrenergic receptor (ADA1B) −5.46
 Protein quaking-A (QKIA) 5.57    Sodium channel protein type 4 subunit alpha B (SC4AB) −5.30
 Inter-alpha-trypsin inhibitor heavy chain H2 (ITIH2) 5.03    Amiloride-sensitive amine oxidase (AOC1) −5.15
 LINE-1 retrotransposable element ORF2 protein (LORF2) 5.02    DNA damage-inducible transcript 4-like protein (DDT4L) −5.03
 Dynein heavy chain 8, axonemal (DYH8) 4.99    Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3 (NDST3) −5.02
 Retrovirus-related Pol polyprotein from transposon 412 (POL4) 4.73    Leukocyte cell-derived chemotaxin-2 (LECT2) −4.89
 Inter-alpha-trypsin inhibitor heavy chain H5 (ITIH5) 4.50    Leukocyte cell-derived chemotaxin 1 (CNMD) −4.89
 WD repeat-containing protein on Y chromosome (WDY) 4.43    Feline leukemia virus subgroup C receptor-related protein 2 (FLVC2) −4.83
 Filamin-C (FLNC) 4.37    Sulfotransferase family cytosolic 2B member 1 (ST2B1) −4.79