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Table 3 Top 25 up- and down-regulated DEGs in the brain at 24 and 72 hpi.

From: RNA-Seq analysis of European sea bass (Dicentrarchus labrax L.) infected with nodavirus reveals powerful modulation of the stress response

Blast2GO UniProt/SwissProt descriptionFCBlast2GO UniProt/SwissProt descriptionFC
24 hpi
 Hydroxytryptamine receptor 3E (5HT3E5)51.82   Prolactin (PRL)−101144.45
 Bile acid-CoA:amino acid N-acyltransferase (BAAT)13.07   Somatolactin (SL)−13670.06
 Actin-related protein 2/3 complex subunit 1A(ARC1A)12.76   Somatotropin (SOMA)–growht hormone (GH)−2711.84
 Collagen alpha-1(X) chain (COAA1)10.87   Gonadotropin subunit beta-2 (GTHB2)−1896.99
 B2 bradykinin receptor (BKRB2)7.36   O-acyltransferase like protein (OACYL)−377.22
 Deoxyribonuclease-1 (DNAS1)6.95   Pro-opiomelanocortin (POMC)−349.84
 Deoxyribonuclease-1 (DNAS1)6.48   Serotransferrin-1 (STF)−240.04
Alkaline phosphatase, tissue-nonspecific isozyme (PPBT)6.20   Thyrotropin subunit beta (TSHB)−172.68
 Proline-rich basic protein 1 (PROB1)4.78   Gonadotropin alpha chain (GLHA)−71.08
 Probable cysteine–tRNA ligase, mitochondrial (SYCM)4.68   Transmembrane protein 130 (TM130)−27.42
 MAGUK p55 subfamily member 4 (MPP4)4.34   LINE-1 type transposase domain-containing protein 1 (LITD1)−18.39
 Acidic repeat-containing protein (ACRC)4.20   Pituitary-specific positive transcription factor 1 (PIT1)−16.88
 Gag-Pol polyprotein (POL)4.14   Troponin T, fast skeletal muscle isoforms (TNNT3)−16.50
 MICAL-like protein 2 (MILK2)4.12   Transcription factor COE1 (COE1)−16.04
 Leucine-rich repeat and coiled-coil domain-containing protein 1 (LRCC1)4.07   Methylmalonyl-CoA mutase, mitochondrial (MUTA)−15.94
 Tetranectin (TETN)3.86   Gonadotropin subunit beta-1 (GTHB1)−12.59
 ATP-binding cassette sub-family A member 1 (ABCA1)3.81   LINE-1 reverse transcriptase homolog (LIN1)−10.49
 Oxysterol-binding protein-related protein 11 (OSB11)3.78   Pituitary homeobox 3 (PITX3)−10.15
 DNA replication complex GINS protein PSF3 (PSF3)3.58   Myosin regulatory light chain 2, skeletal muscle isoform type 2 (MLRS)−9.10
 Filamin-C (FLNC)3.57   NLR family CARD domain containing 3 (NLRC3)−8.70
 Leukocyte cell-derived chemotaxin-2 (LECT2)3.55   LINE-1 retrotransposable element ORF2 protein (LORF2)−8.66
 Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (SAMH1)3.50   UPF0577 protein KIAA1324 (K1324)−8.58
 Protein largen (LARGN)3.41   NADH dehydrogenase (NDUFA1)−7.48
 High affinity choline transporter 1 (SC5A7)3.37   Regulator of rDNA transcription protein 15 (RRT15)−7.20
 Cathepsin D (CATD)3.36   Fructose-bisphosphate aldolase A (ALDOA)−6.90
72 hpi
 Prolactin (PRL)4713.60   Myosin regulatory light chain 2, skeletal muscle isoform type 2 (MLRS)−47.94
 Somatotropin (SOMA)1332.49   Collagen alpha-1(II) chain (CO2A1)−34.45
 Thyrotropin subunit beta (TSHB)27.90   Transposon Ty3-I Gag-Pol polyprotein (YI31B)−30.32
 Probable cysteine–tRNA ligase, mitochondrial (SYCM)25.81   Fructose-bisphosphate aldolase A (ALDOA)−19.98
 Gonadotropin alpha chain (GLHA)19.53   Troponin T, fast skeletal muscle isoforms (TNNT3)−18.43
 Pentraxin-4 (PTX4)13.24   Sodium channel protein type 4 subunit alpha B (SC4AB)−14.00
 Pro-opiomelanocortin (POMC)13.23   Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 (AT2A1)−13.68
 LINE-1 retrotransposable element ORF2 protein (LORF2)10.99   Creatine kinase M-type (KCRM)−12.46
 Serine protease 48 (PRS48)9.97   Actin, alpha skeletal muscle 2 (ACT2)−11.73
 Probable E3 ubiquitin-protein ligase HERC4 (HERC4)8.55   Keratin, type I cytoskeletal 17 (K1C17)−11.31
 Sacsin (SACS)7.07   Parvalbumin alpha (PRVA)−10.45
 C-X-C motif chemokine 9 (CXCL9)7.07   Collagen alpha-1(II) chain (CO2A1)−9.10
 Radical S-adenosyl methionine domain-containing protein 2 (RSAD2)6.63   Keratin, type I cytoskeletal 13 (K1C13)−8.06
 Sacsin (SACS)6.37   DNA damage-inducible transcript 4-like protein (DDT4L)−5.60
 Receptor-transporting protein 3 (RTP3)5.81   Receptor-type tyrosine-protein phosphatase F (PTPRF)−5.58
 Receptor-type tyrosine-protein phosphatase F (PTPRF)5.75   Metabotropic glutamate receptor 8 (GRM8)−5.54
 Complement C3 (CO3)5.66   Alpha-1B adrenergic receptor (ADA1B)−5.46
 Protein quaking-A (QKIA)5.57   Sodium channel protein type 4 subunit alpha B (SC4AB)−5.30
 Inter-alpha-trypsin inhibitor heavy chain H2 (ITIH2)5.03   Amiloride-sensitive amine oxidase (AOC1)−5.15
 LINE-1 retrotransposable element ORF2 protein (LORF2)5.02   DNA damage-inducible transcript 4-like protein (DDT4L)−5.03
 Dynein heavy chain 8, axonemal (DYH8)4.99   Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3 (NDST3)−5.02
 Retrovirus-related Pol polyprotein from transposon 412 (POL4)4.73   Leukocyte cell-derived chemotaxin-2 (LECT2)−4.89
 Inter-alpha-trypsin inhibitor heavy chain H5 (ITIH5)4.50   Leukocyte cell-derived chemotaxin 1 (CNMD)−4.89
 WD repeat-containing protein on Y chromosome (WDY)4.43   Feline leukemia virus subgroup C receptor-related protein 2 (FLVC2)−4.83
 Filamin-C (FLNC)4.37   Sulfotransferase family cytosolic 2B member 1 (ST2B1)−4.79