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Table 3 Top 25 up- and down-regulated DEGs in the brain at 24 and 72 hpi.

From: RNA-Seq analysis of European sea bass (Dicentrarchus labrax L.) infected with nodavirus reveals powerful modulation of the stress response

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Blast2GO UniProt/SwissProt description

FC

Blast2GO UniProt/SwissProt description

FC

24 hpi

 Hydroxytryptamine receptor 3E (5HT3E5)

51.82

   Prolactin (PRL)

−101144.45

 Bile acid-CoA:amino acid N-acyltransferase (BAAT)

13.07

   Somatolactin (SL)

−13670.06

 Actin-related protein 2/3 complex subunit 1A(ARC1A)

12.76

   Somatotropin (SOMA)–growht hormone (GH)

−2711.84

 Collagen alpha-1(X) chain (COAA1)

10.87

   Gonadotropin subunit beta-2 (GTHB2)

−1896.99

 B2 bradykinin receptor (BKRB2)

7.36

   O-acyltransferase like protein (OACYL)

−377.22

 Deoxyribonuclease-1 (DNAS1)

6.95

   Pro-opiomelanocortin (POMC)

−349.84

 Deoxyribonuclease-1 (DNAS1)

6.48

   Serotransferrin-1 (STF)

−240.04

Alkaline phosphatase, tissue-nonspecific isozyme (PPBT)

6.20

   Thyrotropin subunit beta (TSHB)

−172.68

 Proline-rich basic protein 1 (PROB1)

4.78

   Gonadotropin alpha chain (GLHA)

−71.08

 Probable cysteine–tRNA ligase, mitochondrial (SYCM)

4.68

   Transmembrane protein 130 (TM130)

−27.42

 MAGUK p55 subfamily member 4 (MPP4)

4.34

   LINE-1 type transposase domain-containing protein 1 (LITD1)

−18.39

 Acidic repeat-containing protein (ACRC)

4.20

   Pituitary-specific positive transcription factor 1 (PIT1)

−16.88

 Gag-Pol polyprotein (POL)

4.14

   Troponin T, fast skeletal muscle isoforms (TNNT3)

−16.50

 MICAL-like protein 2 (MILK2)

4.12

   Transcription factor COE1 (COE1)

−16.04

 Leucine-rich repeat and coiled-coil domain-containing protein 1 (LRCC1)

4.07

   Methylmalonyl-CoA mutase, mitochondrial (MUTA)

−15.94

 Tetranectin (TETN)

3.86

   Gonadotropin subunit beta-1 (GTHB1)

−12.59

 ATP-binding cassette sub-family A member 1 (ABCA1)

3.81

   LINE-1 reverse transcriptase homolog (LIN1)

−10.49

 Oxysterol-binding protein-related protein 11 (OSB11)

3.78

   Pituitary homeobox 3 (PITX3)

−10.15

 DNA replication complex GINS protein PSF3 (PSF3)

3.58

   Myosin regulatory light chain 2, skeletal muscle isoform type 2 (MLRS)

−9.10

 Filamin-C (FLNC)

3.57

   NLR family CARD domain containing 3 (NLRC3)

−8.70

 Leukocyte cell-derived chemotaxin-2 (LECT2)

3.55

   LINE-1 retrotransposable element ORF2 protein (LORF2)

−8.66

 Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (SAMH1)

3.50

   UPF0577 protein KIAA1324 (K1324)

−8.58

 Protein largen (LARGN)

3.41

   NADH dehydrogenase (NDUFA1)

−7.48

 High affinity choline transporter 1 (SC5A7)

3.37

   Regulator of rDNA transcription protein 15 (RRT15)

−7.20

 Cathepsin D (CATD)

3.36

   Fructose-bisphosphate aldolase A (ALDOA)

−6.90

72 hpi

 Prolactin (PRL)

4713.60

   Myosin regulatory light chain 2, skeletal muscle isoform type 2 (MLRS)

−47.94

 Somatotropin (SOMA)

1332.49

   Collagen alpha-1(II) chain (CO2A1)

−34.45

 Thyrotropin subunit beta (TSHB)

27.90

   Transposon Ty3-I Gag-Pol polyprotein (YI31B)

−30.32

 Probable cysteine–tRNA ligase, mitochondrial (SYCM)

25.81

   Fructose-bisphosphate aldolase A (ALDOA)

−19.98

 Gonadotropin alpha chain (GLHA)

19.53

   Troponin T, fast skeletal muscle isoforms (TNNT3)

−18.43

 Pentraxin-4 (PTX4)

13.24

   Sodium channel protein type 4 subunit alpha B (SC4AB)

−14.00

 Pro-opiomelanocortin (POMC)

13.23

   Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 (AT2A1)

−13.68

 LINE-1 retrotransposable element ORF2 protein (LORF2)

10.99

   Creatine kinase M-type (KCRM)

−12.46

 Serine protease 48 (PRS48)

9.97

   Actin, alpha skeletal muscle 2 (ACT2)

−11.73

 Probable E3 ubiquitin-protein ligase HERC4 (HERC4)

8.55

   Keratin, type I cytoskeletal 17 (K1C17)

−11.31

 Sacsin (SACS)

7.07

   Parvalbumin alpha (PRVA)

−10.45

 C-X-C motif chemokine 9 (CXCL9)

7.07

   Collagen alpha-1(II) chain (CO2A1)

−9.10

 Radical S-adenosyl methionine domain-containing protein 2 (RSAD2)

6.63

   Keratin, type I cytoskeletal 13 (K1C13)

−8.06

 Sacsin (SACS)

6.37

   DNA damage-inducible transcript 4-like protein (DDT4L)

−5.60

 Receptor-transporting protein 3 (RTP3)

5.81

   Receptor-type tyrosine-protein phosphatase F (PTPRF)

−5.58

 Receptor-type tyrosine-protein phosphatase F (PTPRF)

5.75

   Metabotropic glutamate receptor 8 (GRM8)

−5.54

 Complement C3 (CO3)

5.66

   Alpha-1B adrenergic receptor (ADA1B)

−5.46

 Protein quaking-A (QKIA)

5.57

   Sodium channel protein type 4 subunit alpha B (SC4AB)

−5.30

 Inter-alpha-trypsin inhibitor heavy chain H2 (ITIH2)

5.03

   Amiloride-sensitive amine oxidase (AOC1)

−5.15

 LINE-1 retrotransposable element ORF2 protein (LORF2)

5.02

   DNA damage-inducible transcript 4-like protein (DDT4L)

−5.03

 Dynein heavy chain 8, axonemal (DYH8)

4.99

   Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3 (NDST3)

−5.02

 Retrovirus-related Pol polyprotein from transposon 412 (POL4)

4.73

   Leukocyte cell-derived chemotaxin-2 (LECT2)

−4.89

 Inter-alpha-trypsin inhibitor heavy chain H5 (ITIH5)

4.50

   Leukocyte cell-derived chemotaxin 1 (CNMD)

−4.89

 WD repeat-containing protein on Y chromosome (WDY)

4.43

   Feline leukemia virus subgroup C receptor-related protein 2 (FLVC2)

−4.83

 Filamin-C (FLNC)

4.37

   Sulfotransferase family cytosolic 2B member 1 (ST2B1)

−4.79