Figure 4
Fetal gene expression associated with peripheral thyroid hormone reception. Genes associated with uptake (SLC16A2 & SLC16A10), modification (DIO2 & DIO3) and reception (THRA, THRB, ITGAV &ITGB3) of thyroid hormone in the heart (A) and brain (B) tissue of fetuses derived from gestational day matched, non-inoculated control gilts (CON n = 10 heart and 12 brain) and from PRRSV2 challenged dams at 12 days post-inoculation and classified based on serum and thymic viral load as uninfected (UNIF n = 13 heart and 12 brain), high viral load viable (HV-VIA n = 8 heart and 12 brain) or high viral load meconium stained (HV-MEC n = 16 heart and 12 brain). Gene expression was determined by qPCR and fold changes were calculated relative to the average of the CON with unique superscripts denoting statistical differences (P < 0.05) within a given tissue and gene.