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Table 2 A subset of putative target genes and GO terms of altered host circulating miRNAs afterT. spiralisinfection

From: Comparative expression profiles of host circulating miRNAs in response to Trichinella spiralis infection

Name

Length

log2 (fold change)

FDR

GO term

Target gene

miR-467a-3p

22

11.99

0.005113502

GO:0005515 protein binding

Zinc finger protein 516 (Zfp516)

GO:0046872 metal ion binding

Nuclear factor of activated T cells

GO:0005178 integrin binding

Cytoplasmic, calcineurin dependent 2 (Nfatc2)

GO:0016881 acid-amino acid ligase activity

TGF-beta activated kinase 1/MAP3K7 binding protein 3 (Tab 3)

miR-467d-3p

22

11.99

0.0051135

GO:0005515 protein binding

GO:0008134 transcription factor binding

GO:0005178 integrin binding

GO:0016881 acid-amino acid ligase activity

Vascular endothelial growth factor A (Vegfa)

activating transcription factor 2 (Atf2)

transcription factor 3 (Tcf3)

miR-292a-5p

22

5.78

1.55E − 07

GO:0008092 cytoskeletal protein binding

Cadherin-related family member 1 (Cdhr1)

GO:0019899 enzyme binding

Mast cell immunoglobulin like receptor 1 (Milr1)

GO:0005515 protein binding

Tight junction protein 3 (Tjp3)

GO:0008168 methyltransferase activity

Protein kinase C and casein kinase substrate in neurons 3 (Pacsin3)

miR-376b-3p

21

5.05

0.009988095

GO:0004672 protein kinase activity

Laminin, alpha 5 (Lama5)

GO:0016740 transferase activity

Dual specificity phosphatase 22 (Dusp22)

GO:0042802 identical protein binding

Membrane associated tyrosine/threonine 1 (Pkmyt1) protein kinase

GO:0005216 ion channel activity

calcium/calmodulin-dependent protein kinase IV (Camk4)

miR-664-3p

22

3.56

0.005113502

GO:0005229 intracellular calcium activated chloride channel activity

Protein kinase C substrate 80 K-H (Prkcsh)

GO:0008237 metallopeptidase activity

GO:0005509 calcium ion binding

miR-455-5p

22

−3.04

0.009449003

GO:0042605 peptide antigen binding

Calponin 2 (Cnn2)

GO:0030881 beta-2-microglobulin binding

Phosphatase and actin regulator 1 (Phactr1)

GO:0042608 T cell receptor binding

Protein kinase C, beta (Prkcb)

GO:0004674 protein serine/threonine kinase activity

Alpha-kinase 1 (Alpk1)

GO:0008235 metalloexopeptidase activity

 

miR-125b-5p

22

−3.11

0.005545304

GO:0005515 protein binding

Tight junction associated protein 1 (Tjap1)

GO:0004672 protein kinase activity

Interferon regulatory factor 1 (Irf1)

GO:0016740 transferase activity

Chemokine (C–C motif) receptor 8 (Ccr8); CD247 antigen (Cd247)

GO:0004222 metalloendopeptidase activity

MAP/microtubule affinity regulating kinase 2 (Mark2)

miR-125a-5p

24

−3.21

0.005113502

GO:0005515 protein binding

Tubulin, gamma complex associated protein 6 (Tubgcp6)

GO:0003779 actin binding

Interleukin 6 signal transducer (Il6st)

GO:0004674 protein serine/threonine kinase activity

Protein kinase C, zeta (Prkcz)

GO:0008237 metallopeptidase activity

Chemokine (C–C motif) receptor 9 (Ccr9)

miR-615-3p

22

−3.369881789

0.005545304

GO:0005515 protein binding

GO:0004712 protein serine/threonine/tyrosine kinase activity

GO:0008092 cytoskeletal protein binding

GO:0016787 hydrolase activity

Zinc finger protein 592 (Zfp592)

CD40 antigen (Cd40)

Dual specificity Phosphatase 6 (Dusp6)

Dynamin binding protein (Dnmbp)

miR-199a-5p

23

−3.557273923

0.003171509

GO:0019901 protein kinase binding

GO:0050839 cell adhesion molecule binding

GO:0051011 microtubule minus-end binding

GO:0008233 peptidase activity

Protein kinase N1 (Pkn1)

Phosphodiesterase 10A (Pde10a)

Junction plakoglobin (Jup)

Protein kinase C, zeta (Prkcz)