In vitro efficacy of the drugs againstE. multilocularismetacestodes. A The release of alkaline phosphatase activity from E. multilocularis metacestodes (EmAP) after treatment with LND, 6-AN, and their combination. *p < 0.05 vs. DMSO control. B Morphologies of metacestodes after 5 days of treatment with LND, 6-AN, and their combination. a Metacestodes in culture medium containing 0.2% DMSO. Note the typical morphology of the germinal cells. GL, germinal layer; b–e Metacestodes treated with 40 μM 6-AN, 40 μM LND, 20 μM LND + 20 μM 6-AN and 40 μM LND + 40 μM 6-AN, respectively.