Schematic overview of PrPSc deposition in the CNS and ganglia. PrPSc was observed throughout the CNS and in dorsal root ganglia and trigeminal ganglia of scrapie-positive animals. Generally, the PRNP+/Ter animals had slightly higher levels of PrPSc than PRNP+/+ animals in the cranial part of the brain and in the spinal cord. The PRNP+/+ goats had more PrPSc accumulation in the ganglia than the heterozygous goats. No PrPSc was observed in PRNPTer/Ter goats. Abbreviations: C/P, caudate nucleus and putamen; T, thalamus; H, hippocampus; TG, trigeminal ganglion; DH, dorsal horn; VH, ventral horn; WM, white matter; DRG, dorsal root ganglion. Graded red color indicates the magnitude of PrPSc accumulation, whereas grey color are brain regions that were not examined. This scheme summarizes the data described in Additional file 4.