Timeline of clinical and neurological signs. Goats of three different genotypes (4 PRNP+/+, 4 PRNP+/Ter and 4 PRNPTer/Ter) were intracerebrally inoculated with goat scrapie prions at day 0. The figure illustrates the progression of nine selected clinical signs at the indicated days after inoculation (dpi). Neurological exams were performed in all animals at each time point until euthanasia. *Goat 469 had early signs of alopecia associated with an allergic dermatitis. Goat 476 had mild signs of alopecia, and generally a dull and flaking coat not related to scrapie.