Table 2 Overview of the efficacy data

RDS

−6 until 56

0.01 ± 0.01

0.68 ± 0.32^b

0.42 ± 0.33^ab

0.33 ± 0.35^ab

0.26 ± 0.15^a

0.011

−6 until 27

0.00 ± 0.00

0.00 ± 0.00^a

0.00 ± 0.00^a

0.00 ± 0.00^a

0.00 ± 0.01^a

0.415

28 until 56

0.01 ± 0.03

1.47 ± 0.69^b

0.90 ± 0.73^ab

0.73 ± 0.77^ab

0.56 ± 0.33^a

0.011

ADG in g/pig/d

0 until 56

691 ± 69

655 ± 109^a

610 ± 90^a

628 ± 97^a

688 ± 49^a

0.065

0 until 28

620 ± 47

592 ± 104^a

560 ± 104^a

586 ± 106^a

581 ± 70^a

0.526

28 until 56

762 ± 98

739 ± 141^ab

660 ± 96^a

669 ± 127^a

795 ± 69^b

0.004

Number of animals with macroscopic lung lesions (% positive animals)

56

0/5 (0.00)

11/11 (100.00)

7/12 (58.33)

7/12 (58.33)

7/12 (58.33)

–

Macroscopic lung lesion score

56

0.00 ± 0.00

7.57 ± 5.18^b

2.28 ± 3.55^a

1.43 ± 2.31^a

0.88 ± 1.01^a

0.002

Microscopic lung lesion score

56

1.13 ± 0.18

3.73 ± 0.94^b

2.11 ± 0.89^a

2.22 ± 0.87^a

1.78 ± 0.57^a

< 0.001

Percentage of lung area occupied by air

56

39.11 ± 6.26

23.38 ± 6.43^b

37.57 ± 5.99^a

34.82 ± 4.28^ab

42.15 ± 7.98^a

< 0.001

Number of animals positive for M. hyopneumoniae in BAL fluid (% positive animals)

42

0/5

11/11 (100.00)

9/11 (81.82)

9/12 (75.00)

6/12 (50.00)

–

56

0/5

8/11 (72.73)

5/12 (41.67)

6/12 (50.00)

4/12 (33.33)

–

Log copies M. hyopneumoniae DNA/mL BAL fluid

42

0.00 ± 0.00

3.82 ± 0.71^b

2.50 ± 1.18^ab

2.20 ± 1.38^a

1.25 ± 1.28^a

< 0.001

56

0.00 ± 0.00

1.74 ± 0.94^a

1.24 ± 1.34^a

1.76 ± 1.68^a

0.63 ± 0.74^a

0.082