Table 5 Antibiotic resistance genes found in 20 S. ruminantium genomes
Genesb | Isolation sites | Â | Â | Â | Â | Â | Â | Â | Â | Â |
|---|---|---|---|---|---|---|---|---|---|---|
Heart | Â | Â | Abscess | Â | Â | Lung | Â | Â | Â | |
Chromosomal location of genomic islands carrying the antibiotic resistance genesa | Â | Â | Â | Â | Â | Â | Â | Â | Â | |
– | Location 3 | Location 3 | – | – | – | Location 4 | Location 4 | Location 4 | Location 4, UNK | |
DAT741 | DTK364 | DTK390 | DTK285 | DTK284 | MO591 | DTK360 | DTK397 | DTK366 | DAT837 | |
tetM | – | – | – | – | – | – | – | – | – | – |
tetO | – | + | + | – | – | – | + | + | + | + |
sat-4 | – | – | – | – | – | – | – | – | – | + |
aad (6) | – | – | – | – | – | – | – | – | – | + |
aadK | – | – | – | – | – | – | – | – | – | – |
ant(6)-Ib | – | – | – | – | – | – | + | + | + | – |
ermB | – | – | – | – | – | – | + | + | + | + |
aph(3′)-IIIa | – | – | – | – | – | – | – | – | – | + |
catD | – | – | – | – | – | – | – | – | – | + |
cat-TC | – | – | – | – | – | – | – | – | – | + |
Genesb | Isolation sites | Function | Confer resistance to | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Tonsils or oral cavity | ||||||||||||
Chromosomal location of genomic islands carrying the antibiotic resistance genesa | ||||||||||||
Location 2 | UNK | Location 4 | Location 3 | Location 3 | – | – | Location 1 | Location 4 | – | |||
MO402 | DTK377 | MO430 | MO449 | MO492 | MO498 | MO505 | MO512 | MO533 | MO557 | |||
tetM | – | – | – | – | – | – | – | + | – | – | Tetracycline-resistant ribosomal protection protein | Tetracycline, doxycycline, minocycline, oxytetracycline, etc. |
tetO | – | + | + | + | + | – | – | – | + | – | ||
sat-4 | + | – | – | – | – | – | – | – | – | – | Streptothricin acetyltransferase | Streptothricin |
aad (6) | – | – | – | – | – | – | – | – | – | – | Aminoglycoside nucleotidyltransferase | Streptomycin |
aadK | + | – | – | – | – | – | – | – | – | – | ||
ant(6)-Ib | – | + | + | + | + | – | – | – | + | – | ||
ermB | – | + | + | + | – | – | – | – | + | – | 23S ribosomal RNA methyltransferase | Erythromycin, clarithromycin, tylosin, vernamycin, etc. |
aph(3′)-IIIa | + | – | – | – | – | – | – | – | – | – | Aminoglycoside phosphotransferase | Kanamycin, gentamicin, ribostamycin, butirosin, etc. |
catD | – | – | – | – | – | – | – | – | – | – | Chloramphenicol acetyltransferase | Chloramphenicol, thiamphenicol, azidamfenicol |
cat-TC | – | – | – | – | – | – | – | – | – | – | ||