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Table 1 Number of positive reactors in each experimental group using different diagnostic tests and antigens

From: Evaluation of the immunogenicity and efficacy of BCG and MTBVAC vaccines using a natural transmission model of tuberculosis

Test Antigen Group T0a T1 T3b T5 T7 T9 T11 T12
IGRA PPD-B cut-off 0.05 Control 0/17 0/17 0/17 2/17 9/15 12/14 10/12 10/12
   BCG 0/17 2/17 6/17 0/17 3/15 7/14 10/14 8/14
   MTBVAC 0/17 14/17 7/17 1/16 5/15 11/13 11/13 12/13
  PPD-B cut-off 0.1 Control 0/17 0/17 0/17 2/17 8/15 12/14 10/12 10/12
   BCG 0/17 2/17 5/17 0/17 1/15 3/14 7/14 6/14
   MTBVAC 0/17 12/17 4/17 0/16 3/15 8/13 6/13 9/13
  E/Cc Control 0/17 0/17 NA 2/17 5/15 11/14 6/12 7/12
   BCG 0/17 0/17 NA 0/17 0/15 0/14 2/14 1/14
   MTBVAC 0/17 3/17 NA 1/16 0/15 4/13 1/13 5/13
  Rv3615c Control 0/17 0/17 NA 1/17 3/15 8/14 3/12 3/12
   BCG 0/17 0/17 NA 0/17 0/15 0/14 0/14 0/14
   MTBVAC 0/17 1/17 NA 0/16 0/15 1/13 1/13 3/13
SIT test PPD-B Control NA NA 1/17 2/17 NA 11/14 NA 11/12
   BCG NA NA 15/17 4/17 NA 2/14 NA 11/14
   MTBVAC NA NA 15/17 1/16 NA 8/13 NA 12/13
  E/C Control NA NA NA 2/17 NA 9/14 NA 6/12
   BCG NA NA NA 1/17 NA 2/14 NA 2/14
   MTBVAC NA NA NA 0/16 NA 5/13 NA 5/13
SCIT test PPD-B and PPD-A Control NA NA 0/17 2/17 NA 7/14 NA 10/12
   BCG NA NA 10/17 1/17 NA 1/14 NA 8/14
   MTBVAC NA NA 11/17 0/16 NA 6/13 NA 9/13
P22_ELISA (E% 100) P22 and PPD-A Control 0/17 0/17 0/17 0/17 3/15 2/14 8/12 6/12
   BCG 0/17 0/17 0/17 3/17 5/15 2/14 11/14 13/14
   MTBVAC 0/17 1/17 0/17 3/16 8/15 1/13 12/13 10/13
P22_ELISA (E% 150) P22 and PPD-A Control 0/17 0/17 0/17 0/17 2/15 2/14 4/12 6/12
   BCG 0/17 0/17 0/17 2/17 2/15 1/14 4/14 5/14
   MTBVAC 0/17 1/17 0/17 0/16 3/15 0/13 4/13 8/13
  1. E%, ELISA percentage for interpretation and cut-off point; E/C, cocktail of ESAT-6/CFP-10; IGRA, interferon-gamma release assay; NA, not available; PPD-B, bovine purified protein derivative; PPD-A, avian purified protein derivative; SIT, single intradermal tuberculin test; SCIT, single comparative intradermal tuberculin test.
  2. aVaccination (time in months).
  3. bExposure to infected animals.
  4. cCut-off 0.1.
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Veterinary Research

ISSN: 1297-9716