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Table 2 Amino acid differences in HA protein sequences of the H1 av N2 viruses described in this study as compared to HA residues in reference strain A/Sw/Cotes d’Armor/0388/09 (CA/388/09)

From: Virus persistence in pig herds led to successive reassortment events between swine and human influenza A viruses, resulting in the emergence of a novel triple-reassortant swine influenza virus

CA/388/09a

A-11

A-12

B-14

A-16

Reported effectc

V14

Ab

Ab

Ab

Ab

V22

I

I

I

I

S53

N

N

N

N

Antigenic drift/escape mutant

Q68

H

H

H

H

V74

I

I

L86

S

S

P

P

L88

P

Antigenic drift/escape mutant

S154

P

P

P

P

Antigenic drift/escape mutant

S156

L

L

Antigenic drift/escape mutant

G172

R

Antigenic drift/escape mutant and other

L178

I

K186

R

R

G187

E

I192

Vb

Vb

Vb

Vb

D202

V

V

T249

I

I

I

I

H270

Y

G277

S

S

S

S

Creates a new potential N-glycosylation site at position 275

V282

Ib

Ib

Ib

Ib

D286

N

N

N

N

H288

N

N

N

Y300

Hb

Hb

Hb

Hb

K304

N

N

S305

G

G

G

N306

S

S

S

S

E319

K

G391

R

R

R

R

Virulence

S393

N

N

N

N

I444

V

V

K460

R

R

R

R

E516

K

  1. Swine H1avN2 reassortants were abbreviated A-11 for A/Sw/France/37-110543/2011 [Farm A], A-12 for A/Sw/France/37-120345/2012 [Farm A], B-14 for A/Sw/France/61-140350/2014 [Farm B] and A-16 for A/Sw/France/37-160178/2016 [Farm A].
  2. aCA/388/09 is a reference strain representative of European swine avian-like H1avNy viruses belonging to the HA clade 1C.2.1 (after Anderson et al. [10]).
  3. bResidue fixed in French swIAV strains of avian-like H1 (H1av) lineage since 2000’.
  4. cAccording to the BII FluSurver.