|
Amino acid changes in swine H1avN2 strains
|
Reported effectsb
|
Frequency of amino acid change in human or swine strains available in IRDa
|
|---|
|
NY/55/01
|
A-11
|
A-12
|
B-14
|
A-16
|
Human 1957–1980 (N = 323)
|
Human 2000–2005 (N = 1921)
|
Human 2011–2016 (N = 8108)
|
Swine 2011–2016 (N = 4397)
|
|---|
|
T19
|
A
|
A
|
A
|
A
|
–
|
0.31
|
6.98
|
0.04
|
4.82
|
|
L23
|
F
|
F
|
F
|
F
|
–
|
0.31
|
47.11
|
98.87
|
5.53
|
|
A27
|
V
|
V
|
V
|
V
|
–
|
0
|
0.57
|
0.037
|
0.32
|
|
Y40
|
H
|
H
|
H
|
H
|
–
|
39.01
|
22.12
|
0.54
|
76.64
|
|
N47
|
T
|
T
|
T
|
I
|
–
|
0
|
0
|
0
|
1.07
|
|
A56
|
T
|
I
|
I
|
I
|
–
|
2.48(T)/97.21 (I)
|
97.19(T)/0.10 (I)
|
99.68(T)/0.19(I)
|
93.43(T)/4.21(I)
|
|
V66
|
–
|
–
|
M
|
M
|
–
|
0.31
|
0
|
0.11
|
0.86
|
|
E199
|
–
|
–
|
–
|
K
|
–
|
80.80
|
61.84
|
99.46
|
37.89
|
|
K221
|
N
|
N
|
N
|
N
|
Antigenic drift/escape mutant
|
99.69
|
1.04
|
0.78
|
81.49
|
|
K249
|
R
|
R
|
R
|
R
|
–
|
97.83
|
1.09
|
0.47
|
12.05
|
|
I254
|
V
|
V
|
V
|
V
|
–
|
0.31
|
0
|
0.30
|
1.02
|
|
V263
|
–
|
–
|
I
|
I
|
–
|
0.31
|
2.97
|
0.60
|
57.90
|
|
S271
|
N
|
N
|
N
|
N
|
–
|
0
|
0.10
|
0.16
|
0.23
|
|
Q273
|
H
|
H
|
H
|
H
|
–
|
0
|
0.05
|
0.01
|
0.07
|
|
N329
|
K
|
K
|
K
|
K
|
Antigenic drift/escape mutant, removes a potential N-glycosylation site
|
0
|
0.05
|
0.78
|
0.18
|
|
H336
|
R
|
–
|
–
|
–
|
–
|
0
|
0.05
|
0.04
|
0.45
|
|
D339
|
G
|
G
|
G
|
G
|
–
|
0
|
0.21
|
0.37
|
0.18
|
|
N358
|
H
|
H
|
H
|
H
|
–
|
0
|
0
|
0
|
0.07
|
|
S372
|
L
|
L
|
L
|
L
|
Antigenic drift/escape mutant
|
0.31
|
2.03
|
98.00
|
81.74
|
|
G401
|
–
|
–
|
D
|
D
|
–
|
70.59
|
2.76
|
0.42
|
10.98
|
|
E432
|
–
|
–
|
–
|
K
|
Antigenic drift/escape mutant
|
0
|
0.16
|
0.15
|
1.55
|
|
I469
|
M
|
M
|
M
|
M
|
–
|
0
|
0.10
|
0.04
|
3.78
|
- Swine H1avN2 reassortants were abbreviated as following: A-11 for A/Sw/France/37-110543/2011 [Farm A], A-12 for A/Sw/France/37-120345/2012 [Farm A], B-14 for A/Sw/France/61-140350/2014 [Farm B] and A-16 for A/Sw/France/37-160178/2016 [Farm A].
- aFrequency based on the occurrence of the mutated residue in N2 proteins from human or swine IAV strains whose sequences available in the Influenza Research Database on April, 16th 2019.
- bAccording to the BII FluSurver.
