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Table 2 Trichinella spiralis proteins involved in molting that are upregulated in 10 h IIL

From: Label-free quantitative proteomic analysis of molting-related proteins of Trichinella spiralis intestinal infective larvae

Protein name Protein IDs Gene name Theor. MW (kDa) IIL/ML P value Unique peptides Coverage (%) GO annotations
Cuticle structural elements
 Cuticle collagen 14 E5RZT0 Tsp_11095 32.91 23.00 0.0107 5 15.60 CC: collagen trimer; integral component of membrane; MF: structural constituent of cuticle
 Putative nematode cuticle collagen N-domain protein E5SQP6 Tsp_09393 59.89 8.12 0.0496 4 6.30 CC: collagen trimer; integral component of membrane; MF: structural constituent of cuticle
 Cuticle collagen rol-6 E5SQP9 Tsp_09396 39.15 3 13.60 CC: collagen trimer; integral component of membrane; MF: structural constituent of cuticle
 Cuticle collagen lon-3 A0A0V1BMR6 lon-3 43.45 3 12.20 CC: collagen trimer; integral component of membrane; MF: structural constituent of cuticle
 Cuticle collagen dpy-7 E5SR67 Tsp_09560 29.37 6 26.60 CC: collagen trimer
 Cuticle collagen 6 Protein roller-8 E5SAG9 rol-8 35.18 3 9.50 CC: collagen trimer; integral component of membrane; MF: structural constituent of cuticle
 Cuticle collagen sqt-1 A0A0V1BL19 sqt-1 34.73 10 40.00 CC: collagen trimer; integral component of membrane; MF: structural constituent of cuticle
 Putative cuticle collagen 2 E5S488 Tsp_03639 26.52 3 21.10 CC: collagen trimer; integral component of membrane; MF: structural constituent of cuticle
 Putative PAN domain protein E5S7X4 Tsp_07811 67.36 15.61 0.0001 14 36.20 BP: cuticle pattern formation; embryonic ectodermal digestive tract morphogenesis; CC: cytoplasmic side of apical plasma membrane; external side of apical plasma membrane; extracellular space; supramolecular fiber; MF: structural constituent of cuticle
Regulators of cuticle synthesis, maintenance, remodeling and degradation
 Zinc carboxypeptidase superfamily E5SP83 Tsp_09758 55.37 5 14.00 MF: metallocarboxypeptidase activity; zinc ion binding
 Putative zinc metalloproteinase nas-13 E5S4Y1 Tsp_05948 19.96 2 11.80
 Metalloendopeptidase A0A0V1C237 TFE3 99.70 16 23.50 BP: protein complex oligomerization; protein maturation by iron-sulfur cluster transfer; MF: metalloendopeptidase activity; zinc ion binding
 Cathepsin B S5M797 37.40 2.29 0.0208 2 7.90 MF: cysteine-type peptidase activity
 Cathepsin F E5SFB3 Tsp_02382 41.90 3.26 0.0145 8 25.40 MF: cysteine-type peptidase activity
Attachment components
 Transmembrane cell adhesion receptor mua-3 A0A0V1BV71 mua-3 402.52 3.14 0.0326 1 3.10 CC: collagen-containing extracellular matrix; integral component of membrane; MF: calcium ion binding; extracellular matrix structural constituent
 Transmembrane matrix receptor MUP-4 A0A0V1BTR4 mup-4 280.00 2.03 0.0159 49 27.90 CC: collagen-containing extracellular matrix; integral component of membrane; MF: calcium ion binding; extracellular matrix structural constituent
 E3 ubiquitin-protein ligase listerin A0A0V1B0D3 ltn1 201.88 2.34 0.0007 25 19.40 BP: ribosome-associated ubiquitin-dependent protein catabolic process; CC: RQC complex; MF: ligase activity; ubiquitin protein ligase activity
Hormonal regulation of molting
 Cytochrome P450 4V2 E5SY27 Tsp_10837 57.31 8.59 0.0001 22 47.40 CC: integral component of membrane; MF: heme binding; iron ion binding; monooxygenase activity;
 Putative nuclear hormone receptor HR3 A0A0V1AYJ5 Hr46 53.37 1 2.70 CC: nucleus; MF: nuclear receptor activity; sequence-specific DNA binding; steroid hormone receptor activity
Intracellular trafficking components and regulators
 Low-density lipoprotein receptor-related protein A0A0V1B0U4 lrp-1 74.61 13 31.00 CC: integral component of membrane; calcium ion binding
 Serine/threonine-protein kinase RIO1 A0A0V1BAH6 Riok1 59.34 3 7.00 MF: ATP binding; protein serine/threonine kinase activity
  1. CC: cellular component, MF: molecular function, BP: biological process.