Skip to main content

Table 1 Clinical outcome, serology, histopathology, and parasite detection in tissues for Nc-Spain7 infected foetuses and calves

From: Effects of challenge dose and inoculation route of the virulent Neospora caninum Nc-Spain7 isolate in pregnant cattle at mid-gestation

Group (dose, route)

Animal ID

Foetal death (dpi)/calf

N. caninum-specific IgG

Histopathology (HE, IHQ)

N. caninum DNA detection

IFAT titreb

RIPC

Placentome

Brain

Liver

IV1 (107 tachyzoites)

IV1.1

Foetal death (31)

+

9/9

3/3

0/3

IV1.2

Foetal death (25)

+

9/9

3/3

0/3

IV1.3

Foetal death (27)

ND

ND

ND

ND

ND

IV1.4

Calf

3200

14.4

0/10

0/3

IV1.5

Calf

800

7.8

2/10

0/3

IV1.6

Foetal death (30)

+

9/9

3/3

0/3

IV2 (105 tachyzoites)

IV2.1

Foetal death (29)

ND

+

8/8

3/3

1/3

IV2.2

Foetal death (39)

+

9/9

3/3

0/3

IV2.3

Calf

3200

48.5

0/10

0/3

IV2.4

Calf

− 2.5

0/10

0/3

IV2.5

Foetal death (39)

16

+

7/9

3/3

0/3

IV2.6

Calf

6400

60.5

0/10

0/3

SC (105 tachyzoites)

SC.1

Calf

− 4.4

0/10

0/3

SC.2

Foetal death (26)

9/9

3/3

1/3

SC.3

Calf

− 4.4

0/10

0/3

SC.4

Calf

− 4.1

0/10

0/3

SC.5

Calf

− 3.5

0/10

0/3

SC.6

Calf

− 4.5

0/10

0/3

IV3 (103 tachyzoites)

IV3.1

Calf

− 2.9

0/10

0/3

IV3.2

Calf

− 3.1

0/10

0/3

IV3.3

Foetal death (38)

ND

+

8/9

0/3

ND

IV3.4

Calf

− 3.2

0/10

0/3

IV3.5

Calf

50

− 3.3

0/10

0/3

IV3.6

Calf

− 3.1

0/10

0/3

IV4 (102 tachyzoites)

IV4.1

Foetal death (62)

32

+

8/9

0/3

0/3

IV4.2

Foetal death (42)

+

8/9

3/3

0/3

IV4.3

Calf

− 2.9

0/10

0/3

IV4.4

Calf

− 3.2

4/10

0/3

IV4.5

Calf

− 3.7

4/10

0/3

  1. ID: identification, ND: no data are available, IV: intravenous, SC: subcutaneous, HE: haematoxylin–eosin, IHQ: immunohistochemical labelling.