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Figure 5 | Veterinary Research

Figure 5

From: Interleukin-1 signaling induced by Streptococcus suis serotype 2 is strain-dependent and contributes to bacterial clearance and inflammation during systemic disease in a mouse model of infection

Figure 5

Implication of caspase-1 and inflammasomes in S. suis-induced IL-1β bone marrow-derived dendritic cell (bmDC) production is strain-dependent. A Percentage of IL-1β secretion by caspase-1 (CASP-1), NLRP3, AIM2, NLRP1 or NLRC4-deficient bmDCs induced by P1/7 (white bars) or SC84 (gray bars) after 16 h of incubation, in comparison to wild-type counterparts (normalized to 100%); B bmDCs were infected with P1/7 and SC84 strains for 6 h and IL-1β mRNA expression was measured by RT-qPCR. Data are presented as “fold” increase in mRNA expression relative to non-infected cells. C bmDCs were infected with either strain P1/7 or SC84 in the presence of different concentrations of KCl and IL-1β production was measured after 16 h by ELISA. Data are expressed as mean ± SEM (n = 4). *(p < 0.05) indicates a significantly difference with wild-type or non-treated bmDCs and #(p < 0.05) indicates a difference between P1/7 and SC84.

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