Evaluation of a Rhodomyrtus tomentosa ethanolic extract for its therapeutic potential on Staphylococcus aureus infections using in vitro and in vivo models of mastitis

Table 2 Cytotoxicity of the Rhodomyrtus tomentosa leaves (RTL) extract on MAC-T cells as determined by a LDH assay

Concentration (µg/mL)	% cytotoxicity of antibacterial agents^a
Concentration (µg/mL)	R. tomentosa extract	Rhodomyrtone	Pirlimycin
1	6.2 ± 1.4	0.2 ± 0.7	11.5 ± 1.4
2	6.9 ± 0.5	0.2 ± 0.2	14.4 ± 3.2
4	10.5 ± 0.6	0.2 ± 0.2	16.2 ± 1.3
8	10.9 ± 1.1	0.3 ± 0.5	18.9 ± 0.9
16	12.1 ± 0.04	0.4 ± 0.1	20.8 ± 0.5
32	12.7 ± 0.1	0.4 ± 0.3	23.5 ± 1.9
64	14.5 ± 1.8	42.2 ± 0.6	26.6 ± 3.0
128	16.4 ± 3.2	81.9 ± 3.2	28.3 ± 2.7

^aThe % cytotoxicity was calculated as described in “Materials and methods” section. Values are means of three independent experiments with standard deviations. All compounds were diluted and tested in presence of 3.2% DMSO (final concentration).

ISSN: 1297-9716