Table 4 Top 5 down-regulated SDE genes associated with the transcription regulator activity in virus-infected cells
Time (hpi) | Gene symbol | Gene description | rSS1GFP | rSS1GFP-M/NLSm | Molecular function | ||
|---|---|---|---|---|---|---|---|
FCa | P value | FC | P value | ||||
6 | AHR | aryl hydrocarbon receptor | −4.1 | 2.29E−05 | −1.1 | 8.39E−04 | DNA binding transcription factor activity |
NF1A | Nuclear factor I A | −3.5 | 2.04E−04 | −0.8 | 2.43E−03 | RNA polymerase II transcription factor activity | |
TFCP2L1 | Transcription factor CP2 like 1 | −3.0 | 3.27E−06 | −0.4 | 1.66E−02 | RNA polymerase II regulatory region sequence-specific DNA binding | |
SMAD3 | SMAD family member 3 | −2.6 | 2.17E−03 | −0.1 | 2.33E−03 | RNA polymerase II activating transcription factor binding | |
ATXN7L3 | Ataxin 7 like 3 | −2.1 | 1.53E−02 | −0.3 | 1.14E−02 | Transcription activator activity | |
12 | IRF2 | Interferon regulatory factor 2 | −8.7 | 2.87E−07 | −1.2 | 1.57E−02 | Transcriptional activator activity |
AHR | Aryl hydrocarbon receptor | −7.6 | 3.08E−06 | −1.8 | 3.30E−03 | DNA binding transcription factor activity | |
TAF9 | TATA-box binding protein associated factor 9 | −6.5 | 1.36E−06 | −2.0 | 3.98E−04 | RNA polymerase II core promoter sequence-specific binding | |
ATOH8 | Atonal bHLH transcription factor 8 | −5.8 | 3.11E−05 | −1.3 | 3.54E−02 | Transcription factor binding | |
CARF | Calcium responsive transcription factor | −4.6 | 1.23E−04 | −2.1 | 1.71E−02 | Transcriptional activator activity | |
18 | HOXB4 | homeobox B4 | −10.4 | 5.88E−08 | −2.4 | 2.58E−02 | DNA binding transcription factor activity |
AHR | Aryl hydrocarbon receptor | −9.2 | 4.11E−07 | −1.5 | 1.62E−03 | DNA binding transcription factor activity | |
LHX2 | LIM homeobox 2 | −7.9 | 4.27E−07 | −2.7 | 2.89E−04 | Transcription factor activity | |
TBX3 | T-box 3 | −6.5 | 5.68E−06 | −1.4 | 3.26E−03 | RNA polymerase II activating transcription factor binding | |
LMO2 | LIM domain only 2 | −5.7 | 1.35E−06 | −0.8 | 1.25E−02 | RNA polymerase II transcription factor activity | |