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Table 4 Top 5 down-regulated SDE genes associated with the transcription regulator activity in virus-infected cells

From: Nuclear localization of Newcastle disease virus matrix protein promotes virus replication by affecting viral RNA synthesis and transcription and inhibiting host cell transcription

Time (hpi) Gene symbol Gene description rSS1GFP rSS1GFP-M/NLSm Molecular function
FCa P value FC P value
6 AHR aryl hydrocarbon receptor −4.1 2.29E−05 −1.1 8.39E−04 DNA binding transcription factor activity
NF1A Nuclear factor I A −3.5 2.04E−04 −0.8 2.43E−03 RNA polymerase II transcription factor activity
TFCP2L1 Transcription factor CP2 like 1 −3.0 3.27E−06 −0.4 1.66E−02 RNA polymerase II regulatory region sequence-specific DNA binding
SMAD3 SMAD family member 3 −2.6 2.17E−03 −0.1 2.33E−03 RNA polymerase II activating transcription factor binding
ATXN7L3 Ataxin 7 like 3 −2.1 1.53E−02 −0.3 1.14E−02 Transcription activator activity
12 IRF2 Interferon regulatory factor 2 −8.7 2.87E−07 −1.2 1.57E−02 Transcriptional activator activity
AHR Aryl hydrocarbon receptor −7.6 3.08E−06 −1.8 3.30E−03 DNA binding transcription factor activity
TAF9 TATA-box binding protein associated factor 9 −6.5 1.36E−06 −2.0 3.98E−04 RNA polymerase II core promoter sequence-specific binding
ATOH8 Atonal bHLH transcription factor 8 −5.8 3.11E−05 −1.3 3.54E−02 Transcription factor binding
CARF Calcium responsive transcription factor −4.6 1.23E−04 −2.1 1.71E−02 Transcriptional activator activity
18 HOXB4 homeobox B4 −10.4 5.88E−08 −2.4 2.58E−02 DNA binding transcription factor activity
AHR Aryl hydrocarbon receptor −9.2 4.11E−07 −1.5 1.62E−03 DNA binding transcription factor activity
LHX2 LIM homeobox 2 −7.9 4.27E−07 −2.7 2.89E−04 Transcription factor activity
TBX3 T-box 3 −6.5 5.68E−06 −1.4 3.26E−03 RNA polymerase II activating transcription factor binding
LMO2 LIM domain only 2 −5.7 1.35E−06 −0.8 1.25E−02 RNA polymerase II transcription factor activity
  1. aFC: fold change in expression levels relative to those of uninfected cells.