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Table 2 Top five IPA canonical pathways modulated by rSS1GFP and rSS1GFP-M/NLSm

From: Nuclear localization of Newcastle disease virus matrix protein promotes virus replication by affecting viral RNA synthesis and transcription and inhibiting host cell transcription

Time points (hpi) Virus IPA canonical pathwaya P value Gene countb
6 rSS1GFP Toll-like receptor signaling pathway 3.62E−04 3/10
RIG-I-like receptor signaling pathway 4.15E−04 1/8
NF-kappa B signaling pathway 2.18E−03 2/8
Hepatitis C 3.70E−03 2/12
TGF-β signaling pathway 4.53E−03 1/6
rSS1GFP-M/NLSm Apelin signaling pathway 2.15E−03 0/2
Hippo signaling pathway 3.44E−03 1/5
Pyrimidine metabolism 1.35E−02 0/3
12 rSS1GFP Cytokine–cytokine receptor interaction 8.93E−10 8/12
HTLV-1 infection 2.06E−9 9/21
Kaposi sarcoma-associated herpesvirus infection 6.38E−9 10/32
Transcriptional misregulation in cancer 2.28E−8 4/7
TNF signaling pathway 3.80E−7 6/16
rSS1GFP-M/NLSm Thyroid hormone signaling pathway 3.63E−5 3/13
Biosynthesis of amino acids 4.96E−5 1/8
Rap1 signaling pathway 2.11E−4 3/8
Glycine, serine and threonine metabolism 2.25E−3 2/10
Non-small cell lung cancer 2.63E−3 1/9
18 rSS1GFP MAPK signaling pathway 1.01E−11 21/42
TNF signaling pathway 2.70E−10 12/36
MAPK signaling pathway 6.99E−9 9/23
Human papillomavirus infection 1.38E−8 10/21
Transcriptional misregulation in cancer 3.31E−8 15/38
rSS1GFP-M/NLSm DNA replication 1.09E−4 6/44
Neurotrophin signaling pathway 1.51E−3 4/23
Cellular senescence 2.36E−3 3/26
Insulin resistance 4.15E−2 2/15
Caffeine metabolism 7.38E−2 2/12
  1. aTop 5 IPA significant canonical pathways are represented (cutoff for significance, P < 0.05). Only three pathways were detected in rSS1GFP-M/NLSm-infected cells at 6 hpi.
  2. bNumbers of genes are provided as X/Y, where Y is the total number of genes in the pathway and X is the amount of differentially expressed genes in response to viral infection.