Role of p53 in pseudorabies virus replication, pathogenicity, and host immune responses

Table 2 Differential expressed of IFN-related genes in brains of PRV-infected p53 ^−/− and wild-type mice.

Gene ID	Gene name	Gene description	Foldchange^a (p53^−/− vs wild-type)
16362	Irf1	Interferon regulatory factor 1	−8.0
54123	Irf7	Interferon regulatory factor 7	−25.4
15957	Ifit1	Interferon-induced protein with tetratricopeptide repeats 1	−19.6
15958	Ifit2	Interferon-induced protein with tetratricopeptide repeats 2	−12.4
15959	Ifit3	Interferon-induced protein with tetratricopeptide repeats 3	−12.9
667370	Ifit3b	Interferon-induced protein with tetratricopeptide repeats 3b	−10.4
66141	Ifitm3	Interferon induced transmembrane protein 3	−5.7
60440	Iigp1	Interferon inducible GTPase 1	−37.7
71586	Ifih1	Interferon induced with helicase C domain 1	−7.5
99899	Ifi44	Interferon-induced protein 44	−17.6
76933	Ifi27l2a	Interferon alpha-inducible protein 27 like 2A	−9.5
14469	Gbp2	Guanylate binding protein 2	−38.2
55932	Gbp3	Guanylate binding protein 3	−13.3
17472	Gbp4	Guanylate binding protein 4	−31.7
229898	Gbp5	Guanylate binding protein 5	−26.8
100702	Gbp6	Guanylate binding protein 6	−12.0
229900	Gbp7	Guanylate binding protein 7	−6.4
236573	Gbp9	Guanylate binding protein 9	−8.0
626578	Gbp10	Guanylate binding protein 10	−24.6

^a Fold activation represents the fold increase in the level of activation in p53^−/− mice compared with the level of activation in wild-type mice.

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