Figure 3
From: Role of p53 in pseudorabies virus replication, pathogenicity, and host immune responses
Histopathological features of the brains of the p53−/− and wild-type mice following intracranial inoculation. Four- to 8-week-old male p53−/− (n = 7) and wild-type (n = 7) mice were inoculated with 105 TCID50 of PRV (Bartha) intracranially. At 6 days post-infection, the brains of the infected mice were harvested, sectioned, and stained with hematoxylin and eosin. B, C Magnified images of the regions indicated with black rectangles in A. G, H Magnified images of the regions indicated with black rectangles in F. D, E, I, K, M, and O Magnified images of the regions indicated with black rectangles in B, C, G, H, L, and N, respectively. Representative images are shown. N: neurons; G; glial cells; NN: necrotic neurons; NP: neuronophagia; P: Purkinje cells; PS: shrinkage of Purkinje cells; PN: necrotic Purkinje cells; ND: nuclear disintegration of Purkinje cells; H: hyperemia; and PC: perivascular cuffing.