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Table 1 Tg66 and tgRM mice inoculated with CWD

From: Transmission studies of chronic wasting disease to transgenic mice overexpressing human prion protein using the RT-QuIC assay

Mouse strain Inoculum Number of micea Number of mice excludedb Days post-inoculation until euthanasia (range, group average) Clinical suspectsc
Tg66 Elk-2 17 2 600–719, 660 7/17
Tg66 MD-1 19 0 467–719, 631 2/19
Tg66 WTD-1 16 1 503–744, 685 6/16
TgRM Elk-2 19 1 538–748, 706 1/19
TgRM MD-1 15 5 551–748, 692 0/15
TgRM WTD-1 11 2 496–798, 696 2/11
  1. aIncludes the total number of mice inoculated and observed for > 450 days.
  2. bIndicates the number of mice that were inoculated but euthanized prior to 450 days and have been excluded from PrP screening tests with the exception of three tgRM mice that were euthanized at 369, 371 and 432 dpi and tested by RT-QuIC.
  3. cClinical suspects in the tg66 mice included mice that displayed one or more of the following signs: gait abnormalities, hind limb weakness, tremors, kyphosis or weight loss. Clinical suspects in the tgRM mice included two mice with abnormal gait and one thin mouse.