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Figure 6 | Veterinary Research

Figure 6

From: Regulators of Salmonella-host interaction identified by peripheral blood transcriptome profiling: roles of TGFB1 and TRP53 in intracellular Salmonella replication in pigs

Figure 6

Intracellular growth of Salmonella enterica serovar Typhimurium strain LT2 in macrophages. Macrophages were first treated with recombinant protein or protein inhibitor, followed by infection with Salmonella bacteria, incubation for 2 h, treatment with gentamicin (100 µg/mL) for 2 h to kill the extracellular bacteria, and immediate lysis or incubation for an additional 8, 12, or 24 h. Line graphs show the intracellular Salmonella counts after the macrophages were treated with Salmonella bacteria. The filled areas represent the standard deviation of three duplicate samples. A PBMCs treated with recombinant TGFB1 or TGFB1 inhibitor; B murine macrophages (RAW 264.7) treated with recombinant TGFB1 or TGFB1 inhibitor; C PBMCs treated with recombinant TRP53 or TRP53 inhibitor; D murine macrophages (RAW 264.7) treated with recombinant TRP53 or TRP53 inhibitor.

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