Characterization of paucibacillary ileal lesions in sheep with subclinical active infection by Mycobacterium avium subsp. paratuberculosis

Pisanu, Salvatore; Cubeddu, Tiziana; Cacciotto, Carla; Pilicchi, Ylenia; Pagnozzi, Daniela; Uzzau, Sergio; Rocca, Stefano; Addis, Maria Filippa

doi:10.1186/s13567-018-0612-0

Veterinary Research

Table 1 Differential proteins in all PTB, PTB1 and PTB2 vs K samples, respectively

From: Characterization of paucibacillary ileal lesions in sheep with subclinical active infection by Mycobacterium avium subsp. paratuberculosis

Accession	Gene name	Description	All PTB vs K	PTB1 vs K	PTB2 vs K
P62808	H2B	Histone H2B type 1	*138.55*	*159.95*	*122.71*
P63048	UBA52	Ubiquitin-60S ribosomal protein L40	*70.26*	*67.05*	*72.67*
A0JNJ5	MYL1	Myosin light chain 1/3, skeletal muscle isoform	*16.55*	*23.39*	*11.42*
Q17QN3	SNRPN	Small nuclear ribonucleoprotein-associated protein N	*11.68*	*9.08*	*13.31*
A1L595	KRT17	Keratin, type I cytoskeletal 17	*11.29*	13.98^b	*9.06*
A0A0E2WA25	HtpG	Chaperone protein HtpG	8.67	5.32	11.19
A2I7N0	SERPINA3-4	Serpin A3-4	*6.70*	*7.62*	*6.05*
Q9BE41	MYH2	Myosin-2	*5.76*	*5.37*	*5.78*
P22226	CATHL1A	Cathelicidin-1	*5.44*	*3.06*	*7.54*
Q29437	AOCX	Primary amine oxidase, liver isozyme	*5.29*	*5.69*	4.99^b
Q56JX9	FABP2	Fatty acid-binding protein, intestinal	*5.07*	*9.92*	1.43^b
Q3T104	SEC61G	Protein transport protein Sec61 subunit gamma	*4.69*	*4.21*	*5.28*
Q17QB3	ASAH1	Acid ceramidase	*3.75*	*3.11*	*4.17*
P19660	CATHL2	Cathelicidin-2	*3.67*	*2.14*	*5.10*
Q5E972	ORMDL2	ORM1-like protein 2	*3.28*	*2.69*	*3.73*
Q9N0K1	CD47	Leukocyte surface antigen CD47	*2.99*	1.98^b	*3.40*
Q0IIG7	RAB5A	Ras-related protein Rab-5A	*2.89*	1.81^b	*3.70*
P61625	ITGAL	Integrin alpha-L	*2.73*	−1.17^b	*4.14*
Q1JPB0	SERPINB1	Leukocyte elastase inhibitor	*2.64*	1.28^b	*3.72*
P85521	CD163	Scavenger receptor cysteine-rich type 1 protein M130	*2.56*	1.14^b	*3.63*
Q58DS5	RAB13	Ras-related protein Rab-13	*2.50*	2.33	*2.40*
Q9BDK2	AIF1	Allograft inflammatory factor 1	*2.49*	1.13^b	*3.51*
P79106	PAFAH2	Platelet-activating factor acetylhydrolase 2	*2.45*	2.05^b	*2.76*
P09578	MT1C	Metallothionein-1C	*2.44*	2.35	2.43^b
P83095	LACTB	Serine beta-lactamase-like protein LACTB	*2.44*	1.39^b	*3.23*
Q95JC7	SLC1A5	Neutral amino acid transporter B (0)	*2.43*	2.05^b	*2.72*
P55156	MTTP	Microsomal triglyceride transfer protein large subunit	*2.37*	*3.45*	1.56^a
Q2YDN6	RPF2	Ribosome production factor 2 homolog	*2.37*	1.45^b	*3.06*
P00766	CTRA	Chymotrypsinogen A	*2.21*	−*2.76*	*3.60*
Q28035	GSTA1	Glutathione S-transferase A1	*2.11*	*3.73*	−1.11^a
Q599T9	MYD88	Myeloid differentiation primary response protein MyD88	*2.06*	*2.35*	*2.00*
P61955	SUMO2	Small ubiquitin-related modifier 2	*2.04*	1.94^b	*2.12*
Q95115	STAT5A	Signal transducer and activator of transcription 5A	*2.04*	1.66^b	*2.33*
Q3SWY9	RAB28	Ras-related protein Rab-28	1.73^b	*2.42*	–
Q32L48	HIST1H2BN	Histone H2B type 1-N	1.55^b	*2.25*	1.01^b
A7YWK3	KRT73	Keratin, type II cytoskeletal 73	1.49^b	*2.24*	−1.08^b
A2VDL6	ATP1A2	Sodium/potassium-transporting ATPase subunit alpha-2	1.44^b	*2.22*	−1.16^a
Q2TBP0	PSMB7	Proteasome subunit beta type-7	1.64^a	*2.10*	1.30^a
P14568	ASS1	Argininosuccinate synthase	1.40^a	*2.05*	−1.09^b
Q2TBU0	HP	Haptoglobin	8.14^b	–	*13.84*
P00639	DNASE1	Deoxyribonuclease-1	3.97^b	−1.57^b	*6.48*
P30922	CHI3L1	Chitinase-3-like protein 1	3.67^b	1.16^b	*5.80*
Q0P5C2	MTHFD2	Bifunctional methylenetetrahydrofolate dehydrogenase	3.04^b	1.57^b	*3.92*
Q1LZA3	ASNS	Asparagine synthetase	2.44^b	1.25^b	*3.53*
P00760	TRY1	Cationic trypsin	1.92^a	2.33^b	*3.03*
O77775	NCF2	Neutrophil cytosol factor 2	2.25^b	1.20^b	*3.03*
P08169	IGF2R	Cation-independent mannose-6-phosphate receptor	1.11^b	−1.05^b	*2.99*
P28782	S100A8	Protein S100-A8	1.94^b	–	*2.89*
P32592	ITGB2	Integrin beta-2	1.86^b	1.20^b	*2.64*
Q2HJH7	MEMO1	Protein MEMO1	2.31^b	1.85^b	*2.62*
O75601	CASP13	Caspase-13	1.75^a	1.01^a	*2.60*
O77588	PLOD1	Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1	1.91^b	−1.12^b	*2.57*
Q5EAD2	PHGDH	d-3-Phosphoglycerate dehydrogenase	1.98^a	1.27^b	*2.51*
A2VDZ9	VAPB	Vesicle-associated membrane protein-associated protein B	2.15^b	1.72^b	*2.46*
P31408	ATP6V1B2	V-type proton ATPase subunit B	1.12^b	1.06^b	*2.45*
P25326	CTSS	Cathepsin S	2.01^b	1.15^b	*2.38*
A5PJP1	BLOC1S3	Biogenesis of lysosome-related organelles complex 1 sub 3	1.76^b	–	*2.38*
Q29RY9	NPL	N-acetylneuraminate lyase	1.74^a	1.10^a	*2.36*
A5PJN2	ERO1L	ERO1-like protein alpha	1.72^b	1.06^b	*2.30*
Q2TBK3	PLAC9	Placenta-specific protein 9	1.71^a	1.02^b	*2.23*
P31404	ATP6V1A	V-type proton ATPase catalytic subunit A	1.75^a	1.11^b	*2.22*
Q3ZBI6	FHL3	Four and a half LIM domains protein 3	1.70^a	1.03^b	*2.21*
Q3SZZ0	BRIX1	Ribosome biogenesis protein BRX1 homolog	1.88^b	1.47^b	*2.18*
O46563	ATP6V1H	V-type proton ATPase subunit H	1.62^b	1.11^b	*2.16*
P35541	SAA1	Serum amyloid A protein	1.41^b	–	*2.15*
Q17QL5	TMEM30A	Cell cycle control protein 50A	1.82^b	1.49^a	*2.07*
Q865V6	CAPG	Macrophage-capping protein	1.56^b	−1.10^b	*2.05*
Q58D20	NLE1	Notchless protein homolog 1	1.90^b	1.74^b	*2.03*
P06868	PLG	Plasminogen	1.63^b	1.17^b	*2.00*
P80931	MCT1A	Mast cell protease 1A	−1.70^b	1.19^b	−*7.28*
Q6B410	LYSI	Lysozyme C	−1.92^b	−1.07^b	−*4.81*
Q3SZX4	CA3	Carbonic anhydrase 3	−1.74^b	1.03^b	−*4.29*
Q7YRZ7	GZMA	Granzyme A	−1.76^a	−1.16^b	−*2.91*
P19111	ALPI	Intestinal-type alkaline phosphatase	−1.28^b	1.29^b	−*2.62*
A8YXX7	TFF3	Trefoil factor 3	−1.43^b	1.11^b	−*2.54*
Q3T166	MPTX	Mucosal pentraxin	−1.01^a	1.77^b	−*2.52*
Q28106	CNTN1	Contactin-1	−1.40^b	1.12^b	−*2.43*
Q3MHR3	DYNLL2	Dynein light chain 2	−1.63^b	−1.22^b	−*2.16*
Q5EA62	FBLN5	Fibulin-5	−1.49^b	−1.05^b	−*2.16*
Q3MHN0	PSMB6	Proteasome subunit beta type-6	−1.63^b	−1.30^b	−*2.16*
Q3T0Z2	FABP6	Gastrotropin	−1.85^b	−1.65^b	−*2.05*
P31836	NCAM1	Neural cell adhesion molecule 1	−1.49^b	−1.10^b	−*2.02*
Q2M2T1	HIST1H2BK	Histone H2B type 1-K	−1.24^a	−*3.55*	1.20^a
Q3T052	ITIH4	Inter-alpha-trypsin inhibitor heavy chain H4	−0.83^a	−*2.63*	1.82^b
P61823	RNASE1	Ribonuclease, pancreatic	−1.11^a	−*2.60*	1.66^a
Q29RQ9	ORMDL1	ORM1-like protein 1	−1.59^b	−*2.25*	−1.43^b
A1A4Q4	TMA7	Translation machinery-associated protein 7	−1.00^a	−*2.23*	1.41^b
Q32PH8	EEF1A2	Elongation factor 1-alpha 2	−*2.01*	−1.56^a	−2.57
Q0III9	ACTN3	Alpha-actinin-3	−*2.36*	−*2.54*	−*2.24*
P00978	IATR	Inter-alpha-trypsin inhibitor	−*4.09*	−*4.38*	−*3.37*
Q9BE39	MYH7	Myosin-7	−*6.04*	−*6.80*	−*5.23*
Q9BE40	MYH1	Myosin-1	−*6.28*	−*7.08*	−*5.44*
O62664	PTGS1	Prostaglandin G/H synthase 1	−*6.39*	−*7.20*	−*5.54*
Q58DW4	SNRPB	Small nuclear ribonucleoprotein-associated protein B’	−*6.81*	−*7.66*	−*5.90*
Q32KN8	TUBA3	Tubulin alpha-3 chain	−*52.20*	−*60.66*	−*46.68*
Q2HJ86	TUBA1D	Tubulin alpha-1D chain	−*97.29*	−*113.10*	−*87.02*

Differences in abundance are reported as fold changes in the respective sample comparisons. Statistically significant proteins are in bolditalics. The only statistically significant MAP protein is in italics.
In bolditalics: fold change ≤ −2 or ≥ 2, beta-binomial test P ≤ 0.05.
^aFold change ≥ −2 or ≤ 2, beta-binomial test P ≤ 0.05
^bAny fold change with non-significant beta-binomial test.

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