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Table 1 Differential proteins in all PTB, PTB1 and PTB2 vs K samples, respectively

From: Characterization of paucibacillary ileal lesions in sheep with subclinical active infection by Mycobacterium avium subsp. paratuberculosis

Accession

Gene name

Description

All PTB vs K

PTB1 vs K

PTB2 vs K

P62808

H2B

Histone H2B type 1

138.55

159.95

122.71

P63048

UBA52

Ubiquitin-60S ribosomal protein L40

70.26

67.05

72.67

A0JNJ5

MYL1

Myosin light chain 1/3, skeletal muscle isoform

16.55

23.39

11.42

Q17QN3

SNRPN

Small nuclear ribonucleoprotein-associated protein N

11.68

9.08

13.31

A1L595

KRT17

Keratin, type I cytoskeletal 17

11.29

13.98b

9.06

A0A0E2WA25

HtpG

Chaperone protein HtpG

8.67

5.32

11.19

A2I7N0

SERPINA3-4

Serpin A3-4

6.70

7.62

6.05

Q9BE41

MYH2

Myosin-2

5.76

5.37

5.78

P22226

CATHL1A

Cathelicidin-1

5.44

3.06

7.54

Q29437

AOCX

Primary amine oxidase, liver isozyme

5.29

5.69

4.99b

Q56JX9

FABP2

Fatty acid-binding protein, intestinal

5.07

9.92

1.43b

Q3T104

SEC61G

Protein transport protein Sec61 subunit gamma

4.69

4.21

5.28

Q17QB3

ASAH1

Acid ceramidase

3.75

3.11

4.17

P19660

CATHL2

Cathelicidin-2

3.67

2.14

5.10

Q5E972

ORMDL2

ORM1-like protein 2

3.28

2.69

3.73

Q9N0K1

CD47

Leukocyte surface antigen CD47

2.99

1.98b

3.40

Q0IIG7

RAB5A

Ras-related protein Rab-5A

2.89

1.81b

3.70

P61625

ITGAL

Integrin alpha-L

2.73

−1.17b

4.14

Q1JPB0

SERPINB1

Leukocyte elastase inhibitor

2.64

1.28b

3.72

P85521

CD163

Scavenger receptor cysteine-rich type 1 protein M130

2.56

1.14b

3.63

Q58DS5

RAB13

Ras-related protein Rab-13

2.50

2.33

2.40

Q9BDK2

AIF1

Allograft inflammatory factor 1

2.49

1.13b

3.51

P79106

PAFAH2

Platelet-activating factor acetylhydrolase 2

2.45

2.05b

2.76

P09578

MT1C

Metallothionein-1C

2.44

2.35

2.43b

P83095

LACTB

Serine beta-lactamase-like protein LACTB

2.44

1.39b

3.23

Q95JC7

SLC1A5

Neutral amino acid transporter B (0)

2.43

2.05b

2.72

P55156

MTTP

Microsomal triglyceride transfer protein large subunit

2.37

3.45

1.56a

Q2YDN6

RPF2

Ribosome production factor 2 homolog

2.37

1.45b

3.06

P00766

CTRA

Chymotrypsinogen A

2.21

−2.76

3.60

Q28035

GSTA1

Glutathione S-transferase A1

2.11

3.73

−1.11a

Q599T9

MYD88

Myeloid differentiation primary response protein MyD88

2.06

2.35

2.00

P61955

SUMO2

Small ubiquitin-related modifier 2

2.04

1.94b

2.12

Q95115

STAT5A

Signal transducer and activator of transcription 5A

2.04

1.66b

2.33

Q3SWY9

RAB28

Ras-related protein Rab-28

1.73b

2.42

–

Q32L48

HIST1H2BN

Histone H2B type 1-N

1.55b

2.25

1.01b

A7YWK3

KRT73

Keratin, type II cytoskeletal 73

1.49b

2.24

−1.08b

A2VDL6

ATP1A2

Sodium/potassium-transporting ATPase subunit alpha-2

1.44b

2.22

−1.16a

Q2TBP0

PSMB7

Proteasome subunit beta type-7

1.64a

2.10

1.30a

P14568

ASS1

Argininosuccinate synthase

1.40a

2.05

−1.09b

Q2TBU0

HP

Haptoglobin

8.14b

–

13.84

P00639

DNASE1

Deoxyribonuclease-1

3.97b

−1.57b

6.48

P30922

CHI3L1

Chitinase-3-like protein 1

3.67b

1.16b

5.80

Q0P5C2

MTHFD2

Bifunctional methylenetetrahydrofolate dehydrogenase

3.04b

1.57b

3.92

Q1LZA3

ASNS

Asparagine synthetase

2.44b

1.25b

3.53

P00760

TRY1

Cationic trypsin

1.92a

2.33b

3.03

O77775

NCF2

Neutrophil cytosol factor 2

2.25b

1.20b

3.03

P08169

IGF2R

Cation-independent mannose-6-phosphate receptor

1.11b

−1.05b

2.99

P28782

S100A8

Protein S100-A8

1.94b

–

2.89

P32592

ITGB2

Integrin beta-2

1.86b

1.20b

2.64

Q2HJH7

MEMO1

Protein MEMO1

2.31b

1.85b

2.62

O75601

CASP13

Caspase-13

1.75a

1.01a

2.60

O77588

PLOD1

Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1

1.91b

−1.12b

2.57

Q5EAD2

PHGDH

d-3-Phosphoglycerate dehydrogenase

1.98a

1.27b

2.51

A2VDZ9

VAPB

Vesicle-associated membrane protein-associated protein B

2.15b

1.72b

2.46

P31408

ATP6V1B2

V-type proton ATPase subunit B

1.12b

1.06b

2.45

P25326

CTSS

Cathepsin S

2.01b

1.15b

2.38

A5PJP1

BLOC1S3

Biogenesis of lysosome-related organelles complex 1 sub 3

1.76b

–

2.38

Q29RY9

NPL

N-acetylneuraminate lyase

1.74a

1.10a

2.36

A5PJN2

ERO1L

ERO1-like protein alpha

1.72b

1.06b

2.30

Q2TBK3

PLAC9

Placenta-specific protein 9

1.71a

1.02b

2.23

P31404

ATP6V1A

V-type proton ATPase catalytic subunit A

1.75a

1.11b

2.22

Q3ZBI6

FHL3

Four and a half LIM domains protein 3

1.70a

1.03b

2.21

Q3SZZ0

BRIX1

Ribosome biogenesis protein BRX1 homolog

1.88b

1.47b

2.18

O46563

ATP6V1H

V-type proton ATPase subunit H

1.62b

1.11b

2.16

P35541

SAA1

Serum amyloid A protein

1.41b

–

2.15

Q17QL5

TMEM30A

Cell cycle control protein 50A

1.82b

1.49a

2.07

Q865V6

CAPG

Macrophage-capping protein

1.56b

−1.10b

2.05

Q58D20

NLE1

Notchless protein homolog 1

1.90b

1.74b

2.03

P06868

PLG

Plasminogen

1.63b

1.17b

2.00

P80931

MCT1A

Mast cell protease 1A

−1.70b

1.19b

−7.28

Q6B410

LYSI

Lysozyme C

−1.92b

−1.07b

−4.81

Q3SZX4

CA3

Carbonic anhydrase 3

−1.74b

1.03b

−4.29

Q7YRZ7

GZMA

Granzyme A

−1.76a

−1.16b

−2.91

P19111

ALPI

Intestinal-type alkaline phosphatase

−1.28b

1.29b

−2.62

A8YXX7

TFF3

Trefoil factor 3

−1.43b

1.11b

−2.54

Q3T166

MPTX

Mucosal pentraxin

−1.01a

1.77b

−2.52

Q28106

CNTN1

Contactin-1

−1.40b

1.12b

−2.43

Q3MHR3

DYNLL2

Dynein light chain 2

−1.63b

−1.22b

−2.16

Q5EA62

FBLN5

Fibulin-5

−1.49b

−1.05b

−2.16

Q3MHN0

PSMB6

Proteasome subunit beta type-6

−1.63b

−1.30b

−2.16

Q3T0Z2

FABP6

Gastrotropin

−1.85b

−1.65b

−2.05

P31836

NCAM1

Neural cell adhesion molecule 1

−1.49b

−1.10b

−2.02

Q2M2T1

HIST1H2BK

Histone H2B type 1-K

−1.24a

−3.55

1.20a

Q3T052

ITIH4

Inter-alpha-trypsin inhibitor heavy chain H4

−0.83a

−2.63

1.82b

P61823

RNASE1

Ribonuclease, pancreatic

−1.11a

−2.60

1.66a

Q29RQ9

ORMDL1

ORM1-like protein 1

−1.59b

−2.25

−1.43b

A1A4Q4

TMA7

Translation machinery-associated protein 7

−1.00a

−2.23

1.41b

Q32PH8

EEF1A2

Elongation factor 1-alpha 2

−2.01

−1.56a

−2.57

Q0III9

ACTN3

Alpha-actinin-3

−2.36

−2.54

−2.24

P00978

IATR

Inter-alpha-trypsin inhibitor

−4.09

−4.38

−3.37

Q9BE39

MYH7

Myosin-7

−6.04

−6.80

−5.23

Q9BE40

MYH1

Myosin-1

−6.28

−7.08

−5.44

O62664

PTGS1

Prostaglandin G/H synthase 1

−6.39

−7.20

−5.54

Q58DW4

SNRPB

Small nuclear ribonucleoprotein-associated protein B’

−6.81

−7.66

−5.90

Q32KN8

TUBA3

Tubulin alpha-3 chain

−52.20

−60.66

−46.68

Q2HJ86

TUBA1D

Tubulin alpha-1D chain

−97.29

−113.10

−87.02

  1. Differences in abundance are reported as fold changes in the respective sample comparisons. Statistically significant proteins are in bolditalics. The only statistically significant MAP protein is in italics.
  2. In bolditalics: fold change ≤ −2 or ≥ 2, beta-binomial test P ≤ 0.05.
  3. aFold change ≥ −2 or ≤ 2, beta-binomial test P ≤ 0.05
  4. bAny fold change with non-significant beta-binomial test.