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Table 1 Differential proteins in all PTB, PTB1 and PTB2 vs K samples, respectively

From: Characterization of paucibacillary ileal lesions in sheep with subclinical active infection by Mycobacterium avium subsp. paratuberculosis

Accession Gene name Description All PTB vs K PTB1 vs K PTB2 vs K
P62808 H2B Histone H2B type 1 138.55 159.95 122.71
P63048 UBA52 Ubiquitin-60S ribosomal protein L40 70.26 67.05 72.67
A0JNJ5 MYL1 Myosin light chain 1/3, skeletal muscle isoform 16.55 23.39 11.42
Q17QN3 SNRPN Small nuclear ribonucleoprotein-associated protein N 11.68 9.08 13.31
A1L595 KRT17 Keratin, type I cytoskeletal 17 11.29 13.98b 9.06
A0A0E2WA25 HtpG Chaperone protein HtpG 8.67 5.32 11.19
A2I7N0 SERPINA3-4 Serpin A3-4 6.70 7.62 6.05
Q9BE41 MYH2 Myosin-2 5.76 5.37 5.78
P22226 CATHL1A Cathelicidin-1 5.44 3.06 7.54
Q29437 AOCX Primary amine oxidase, liver isozyme 5.29 5.69 4.99b
Q56JX9 FABP2 Fatty acid-binding protein, intestinal 5.07 9.92 1.43b
Q3T104 SEC61G Protein transport protein Sec61 subunit gamma 4.69 4.21 5.28
Q17QB3 ASAH1 Acid ceramidase 3.75 3.11 4.17
P19660 CATHL2 Cathelicidin-2 3.67 2.14 5.10
Q5E972 ORMDL2 ORM1-like protein 2 3.28 2.69 3.73
Q9N0K1 CD47 Leukocyte surface antigen CD47 2.99 1.98b 3.40
Q0IIG7 RAB5A Ras-related protein Rab-5A 2.89 1.81b 3.70
P61625 ITGAL Integrin alpha-L 2.73 −1.17b 4.14
Q1JPB0 SERPINB1 Leukocyte elastase inhibitor 2.64 1.28b 3.72
P85521 CD163 Scavenger receptor cysteine-rich type 1 protein M130 2.56 1.14b 3.63
Q58DS5 RAB13 Ras-related protein Rab-13 2.50 2.33 2.40
Q9BDK2 AIF1 Allograft inflammatory factor 1 2.49 1.13b 3.51
P79106 PAFAH2 Platelet-activating factor acetylhydrolase 2 2.45 2.05b 2.76
P09578 MT1C Metallothionein-1C 2.44 2.35 2.43b
P83095 LACTB Serine beta-lactamase-like protein LACTB 2.44 1.39b 3.23
Q95JC7 SLC1A5 Neutral amino acid transporter B (0) 2.43 2.05b 2.72
P55156 MTTP Microsomal triglyceride transfer protein large subunit 2.37 3.45 1.56a
Q2YDN6 RPF2 Ribosome production factor 2 homolog 2.37 1.45b 3.06
P00766 CTRA Chymotrypsinogen A 2.21 2.76 3.60
Q28035 GSTA1 Glutathione S-transferase A1 2.11 3.73 −1.11a
Q599T9 MYD88 Myeloid differentiation primary response protein MyD88 2.06 2.35 2.00
P61955 SUMO2 Small ubiquitin-related modifier 2 2.04 1.94b 2.12
Q95115 STAT5A Signal transducer and activator of transcription 5A 2.04 1.66b 2.33
Q3SWY9 RAB28 Ras-related protein Rab-28 1.73b 2.42
Q32L48 HIST1H2BN Histone H2B type 1-N 1.55b 2.25 1.01b
A7YWK3 KRT73 Keratin, type II cytoskeletal 73 1.49b 2.24 −1.08b
A2VDL6 ATP1A2 Sodium/potassium-transporting ATPase subunit alpha-2 1.44b 2.22 −1.16a
Q2TBP0 PSMB7 Proteasome subunit beta type-7 1.64a 2.10 1.30a
P14568 ASS1 Argininosuccinate synthase 1.40a 2.05 −1.09b
Q2TBU0 HP Haptoglobin 8.14b 13.84
P00639 DNASE1 Deoxyribonuclease-1 3.97b −1.57b 6.48
P30922 CHI3L1 Chitinase-3-like protein 1 3.67b 1.16b 5.80
Q0P5C2 MTHFD2 Bifunctional methylenetetrahydrofolate dehydrogenase 3.04b 1.57b 3.92
Q1LZA3 ASNS Asparagine synthetase 2.44b 1.25b 3.53
P00760 TRY1 Cationic trypsin 1.92a 2.33b 3.03
O77775 NCF2 Neutrophil cytosol factor 2 2.25b 1.20b 3.03
P08169 IGF2R Cation-independent mannose-6-phosphate receptor 1.11b −1.05b 2.99
P28782 S100A8 Protein S100-A8 1.94b 2.89
P32592 ITGB2 Integrin beta-2 1.86b 1.20b 2.64
Q2HJH7 MEMO1 Protein MEMO1 2.31b 1.85b 2.62
O75601 CASP13 Caspase-13 1.75a 1.01a 2.60
O77588 PLOD1 Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 1.91b −1.12b 2.57
Q5EAD2 PHGDH d-3-Phosphoglycerate dehydrogenase 1.98a 1.27b 2.51
A2VDZ9 VAPB Vesicle-associated membrane protein-associated protein B 2.15b 1.72b 2.46
P31408 ATP6V1B2 V-type proton ATPase subunit B 1.12b 1.06b 2.45
P25326 CTSS Cathepsin S 2.01b 1.15b 2.38
A5PJP1 BLOC1S3 Biogenesis of lysosome-related organelles complex 1 sub 3 1.76b 2.38
Q29RY9 NPL N-acetylneuraminate lyase 1.74a 1.10a 2.36
A5PJN2 ERO1L ERO1-like protein alpha 1.72b 1.06b 2.30
Q2TBK3 PLAC9 Placenta-specific protein 9 1.71a 1.02b 2.23
P31404 ATP6V1A V-type proton ATPase catalytic subunit A 1.75a 1.11b 2.22
Q3ZBI6 FHL3 Four and a half LIM domains protein 3 1.70a 1.03b 2.21
Q3SZZ0 BRIX1 Ribosome biogenesis protein BRX1 homolog 1.88b 1.47b 2.18
O46563 ATP6V1H V-type proton ATPase subunit H 1.62b 1.11b 2.16
P35541 SAA1 Serum amyloid A protein 1.41b 2.15
Q17QL5 TMEM30A Cell cycle control protein 50A 1.82b 1.49a 2.07
Q865V6 CAPG Macrophage-capping protein 1.56b −1.10b 2.05
Q58D20 NLE1 Notchless protein homolog 1 1.90b 1.74b 2.03
P06868 PLG Plasminogen 1.63b 1.17b 2.00
P80931 MCT1A Mast cell protease 1A −1.70b 1.19b 7.28
Q6B410 LYSI Lysozyme C −1.92b −1.07b 4.81
Q3SZX4 CA3 Carbonic anhydrase 3 −1.74b 1.03b 4.29
Q7YRZ7 GZMA Granzyme A −1.76a −1.16b 2.91
P19111 ALPI Intestinal-type alkaline phosphatase −1.28b 1.29b 2.62
A8YXX7 TFF3 Trefoil factor 3 −1.43b 1.11b 2.54
Q3T166 MPTX Mucosal pentraxin −1.01a 1.77b 2.52
Q28106 CNTN1 Contactin-1 −1.40b 1.12b 2.43
Q3MHR3 DYNLL2 Dynein light chain 2 −1.63b −1.22b 2.16
Q5EA62 FBLN5 Fibulin-5 −1.49b −1.05b 2.16
Q3MHN0 PSMB6 Proteasome subunit beta type-6 −1.63b −1.30b 2.16
Q3T0Z2 FABP6 Gastrotropin −1.85b −1.65b 2.05
P31836 NCAM1 Neural cell adhesion molecule 1 −1.49b −1.10b 2.02
Q2M2T1 HIST1H2BK Histone H2B type 1-K −1.24a 3.55 1.20a
Q3T052 ITIH4 Inter-alpha-trypsin inhibitor heavy chain H4 −0.83a 2.63 1.82b
P61823 RNASE1 Ribonuclease, pancreatic −1.11a 2.60 1.66a
Q29RQ9 ORMDL1 ORM1-like protein 1 −1.59b 2.25 −1.43b
A1A4Q4 TMA7 Translation machinery-associated protein 7 −1.00a 2.23 1.41b
Q32PH8 EEF1A2 Elongation factor 1-alpha 2 2.01 −1.56a 2.57
Q0III9 ACTN3 Alpha-actinin-3 2.36 2.54 2.24
P00978 IATR Inter-alpha-trypsin inhibitor 4.09 4.38 3.37
Q9BE39 MYH7 Myosin-7 6.04 6.80 5.23
Q9BE40 MYH1 Myosin-1 6.28 7.08 5.44
O62664 PTGS1 Prostaglandin G/H synthase 1 6.39 7.20 5.54
Q58DW4 SNRPB Small nuclear ribonucleoprotein-associated protein B’ 6.81 7.66 5.90
Q32KN8 TUBA3 Tubulin alpha-3 chain 52.20 60.66 46.68
Q2HJ86 TUBA1D Tubulin alpha-1D chain 97.29 113.10 87.02
  1. Differences in abundance are reported as fold changes in the respective sample comparisons. Statistically significant proteins are in bolditalics. The only statistically significant MAP protein is in italics.
  2. In bolditalics: fold change ≤ −2 or ≥ 2, beta-binomial test P ≤ 0.05.
  3. aFold change ≥ −2 or ≤ 2, beta-binomial test P ≤ 0.05
  4. bAny fold change with non-significant beta-binomial test.