Interspecies transmission to bovinized transgenic mice uncovers new features of a CH1641-like scrapie isolate

Table 4 Transmission of TgBo-passaged Sh294 to wild-type mice

Source	Recipient	Passage #	Survival period^a	n/n ^b_o
TgBoPrP mouse brain infected with Sh294	ICR	1	807 ± 46.9	7/20
		2	515 ± 33.6*	6/6^c
		3	453 ± 40.4*	8/8^d
Sheep brain infected with L-BSE	ICR^f	1	710^d	1/15^e
		2	680 ± 20.2	7/9
		3	702 ± 29.5	9/11

^aSurvival periods are shown as mean survival days ± standard deviation.
^bNumber of PrPres-positive mice out of the total number of challenged mice.
^cTwo out of six mice were suddenly dead without any clinical signs at 477^th and 552^th day. The other four mice developed clinical signs of the disease, such as emaciation, rough fur and kyphosis.
^dTwo out of eight inoculated mice were suddenly dead without any clinical signs at 377^th and 441^th day, respectively. The other six mice developed the same clinical signs as above.
^eThe data for the 1^st passage obtained from our previous study shown in the reference (20).
^fICR mice infected sheep-passaged L-BSE did not show any clinical even at the 3^rd passage.
* P < 0.05.

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