Interspecies transmission to bovinized transgenic mice uncovers new features of a CH1641-like scrapie isolate

Table 2 Transmission of Sh294 to TgOvPrP59 mice

Source	Recipient	Passage #	Survival period^a	PrPres^b
Source	Recipient	Passage #	Survival period^a	Brain	Spleen
Sh294 brain (CH1641-like scrapie)	TgOvPrP59	1	259 ± 24.5	10/10	0/10
		2	233 ± 13.4	5/5	0/5
		3	215 ± 17.9	5/5	0/5

^aSurvival periods are shown as mean survival days ± standard deviation.
^bThe number of analyzed mice is shown together with the results of PrPres detection in the brain and spleen (number of PrPres-positive mice/number of inoculated mice). All mice showed clinical signs of disease, such as clasping.

ISSN: 1297-9716