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Table 1 Variation of the viral load and nucleotide diversity (π) in transmission events and between days of viremia

From: Bottlenecks in the transmission of porcine reproductive and respiratory syndrome virus (PRRSV1) to naïve pigs and the quasi-species variation of the virus during infection in vaccinated pigs

Group

Animal n°

Viremic day

Viral load

π

Difference between donor and recipient

Difference between consecutive samples

Inoculum produced in PAM

N.A.

  

0.0127

  

Inoculated animals

D1

1

7.91E+06

0.0045

−0.0082

 

6

6.04E+05

0.0182

 

+0.0137

13

6.18E+06

0.0239

 

+0.0057

D2

1

1.24E+05

0.0091

−0.0036

 

6

3.23E+05

0.0124

 

+0.0033

13

1.24E+05

0.0115

 

−0.0009

D3

1

1.07E+06

0.0064

−0.0063

 

13

1.15E+07

0.0075

 

+0.0011

D4

6

3.46E+05

0.0117

−0.0010

 

13

2.14E+06

0.0528

 

+0.0411

D5

1

1.11E+06

0.0123

−0.0004

 

13

6.09E+05

0.0132

 

+0.0009

6

1

5.66E+05

0.0305

+0.0178

 

6

1.40E+07

0.0308

 

+0.0003

15

1.97E+05

0.0097

 

−0.0211

7

1

3.60E+06

0.0072

−0.0055

 

13

5.88E+05

0.0524

 

+0.0452

8

1

5.71E+05

0.0064

−0.0063

 

06

7.37E+04

0.0152

 

+0.0088

13

2.66E+06

0.0088

 

−0.0064

9

1

4.81E+06

0.0091

−0.0036

 

6

2.58E+05

0.0041

 

−0.0050

13

1.64E++06

0.0335

 

+0.0294

Naïve infected by contact

R1

1

1.23E+07

0.0031

−0.0151

 

6

4.60E+04

0.0119

 

+0.0088

22

5.99E+03

0.0178

 

+0.0059

R2

1

1.63E+06

0.0108

−0.0090

 

8

2.41E+07

0.0091

 

−0.0017

15

2.25E+03

0.0109

 

+0.0018

R3

3

2.76E+05

0.0134

+0.007

 

10

8.57E+06

0.0165

 

−0.0031

R4

1

3.17E+06

0.0092

−0.0025

 

5

2.90E+08

0.0065

 

+0.0027

R5

3

6.06E+06

0.0069

−0.0054

 

10

5.97E+06

0.0099

 

+0.0030

  1. The table shows the difference in nucleotide diversity between: (i) the transmissible population in sera for the donor before the transmission and the founders in the recipient at the first day of viremia, and (ii) samples of the same animals in different days of the virological course. The difference of nucleotide diversities was calculated by subtracting the π value of a given day from the π value the previous examined day. For the first day of each animal the difference was calculated with regards to the inoculum (inoculated animals) or with regards to the diversity of the donor (D1 to D5) on the likely day of transmission (transmission by contact) to the corresponding recipient (R1 to R5) animals. In italic, the most likely day of transmission for the donor animals.
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Veterinary Research

ISSN: 1297-9716