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Figure 3 | Veterinary Research

Figure 3

From: Visualisation and characterisation of mononuclear phagocytes in the chicken respiratory tract using CSF1R-transgenic chickens

Figure 3

The BALT region in CSF1R-transgenic birds. The BALT of the chicken lung is constitutive, consisting of several GC (A) with tightly packed CSF1R-eGFP+ cells in the light zone and a characteristic halo of MPN surrounding the GC (B). In the GC, CSF1R-transgene+ cells express CD11 (C) and lack MHC II (D). TIM4+ CSF1R-transgene cells are present in the GC known as tingible body macrophages. Outside the GC occasional TIM4+ CSF1R-transgene+ cells were observed (E). CSF1R-eGFP+ cells can be found in regions of the epithelial overlaying the BALT (FAE), called M cells (FH). Lung M cells lack MHC II (F) and TIM4 (G) expression. The M cells express high levels of F-actin (H) similar to IFE cells (I). M cells lack jacalin binding in contrast to the IFE (J). LAMP1 is expressed in CSF1R-transgene+ (yellow arrow, K) and CSF1R-transgene cells (white arrow, L). LAMP1 is also highly expressed by epithelial cells (L). GC are indicated by white dashed lines with halo of cells identified with a yellow dashed circle, epithelial layer is indicated by yellow dashed lines.

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