Figure 3

The E2-a shown therapeutical effects against Echinococcus granulosus sensu stricto in vivo. Mice (n = 5) were intraperitoneally injected with protoscoleces. At 20 weeks after infection, the treated mice were intragastrically administrated with E2-a (100 mg/kg) and albendazole (100 mg/kg) respectively, untreated mice received PBS alone each day for 6 weeks. The representative hydatid cyst (A), the average weight of all cysts per group (n = 5) (B), the representative pathological characteristics (H&E, 10 × 10) (C) and the ultrastructure (SEM) D of the metacestodes are shown respectively. The bar of the upper panel was 50 μm and the bar of the under panel was 10 μm. GC: germinal layer; LL: laminated layer; AD: adventitia.