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Figure 3 | Veterinary Research

Figure 3

From: Porcine sapovirus Cowden strain enters LLC-PK cells via clathrin- and cholesterol-dependent endocytosis with the requirement of dynamin II

Figure 3

Dominant negative (DN) mutants against clathrin- and dynamin-mediated endocytosis reduce PSaV infection. The cells transfected with GFP-tagged wild type (WT) or dominant negative (DN) Eps15, caveolin-1, or dynamin II were incubated with PSaV Cowden (A), CVB3 Nancy (B), or rotavirus Wa (C) strains. Infected GFP-expressing cells were counted after being stained with antibodies specific for each virus. Data for panels AC are presented as mean ± standard deviation of the mean from three independent experiments. Differences were evaluated using one-way ANOVA. *P < 0.05; **P < 0.001; ***P < 0.0001.

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