Table 9 Differential expression profile of genes related to Th1 and Th2 cell differentiation pathways in peritoneal exudate cells from cats with FIP compared to peritoneal cells from healthy cats

KEGG Th1 polarization

 IFNG

Interferon, gamma

7.48E−10

 IL12B

Interleukin 12B

2.91E−06

 IL12RB1

Interleukin 12 receptor, beta 1

2.62E−20

 IL12RB2

Interleukin 12 receptor, beta 2

3.50E−08

 STAT1

Signal transducer and activator of transcription 1, 91 kDa

2.72E−11

 TYK2

Tyrosine kinase 2

8.23E−09

 TBX21

T-box 21

0.00033

 JAK2

Janus kinase 2

4.96E−07

 MAML1

Mastermind-like 1 (Drosophila)

4.14E−06

 RBPJL

Recombination signal binding protein for immunoglobulin kappa J region-like

0.22008

 RELA

v-rel avian reticuloendotheliosis viral

0.00019

 STAT4

Signal transducer and activator of transcription 4

0.00289

 IFNGR1

Interferon gamma receptor 1

0.39809

 DLL1

Delta-like 1 (Drosophila)

1.65E −10

 NOTCH3

Notch 3

4.20E −15

KEGG Th2 polarization

 IL6^a

Interleukin 6

0.00071

 IL2RG

Interleukin 2 receptor, gamma

7.33E−20

 PRDMI^a

Blimp-1, PR domain containing 1, with ZNF domain

5.13E−10

 CD40^a

TNFSF5, tumor necrosis factor super family 5

1.65E−17

 IL4R

Interleukin 4 receptor

7.44E−13

 BAFF^a

TNFS13B, tumor necrosis factor super family 13B

4.41E−06 ^b

 GATA3

GATA binding protein 3

0.01676

 RBPJL

Recombination signal binding protein for immunoglobulin kappa J region-like

0.22008

 IL2RA

Interleukin 2 receptor, alpha

0.67473

 STAT6

Signal transducer and activator of transcription 6, interleukin-4 induced

0.75754

IL4

Interleukin 4

0.01694

NOTCH2

Notch 2

0.58684

 MAML3

Mastermind-like 3 (Drosophila)

0.02175

 JAG2

Jagged 2

6.33E −10