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Table 9 Differential expression profile of genes related to Th1 and Th2 cell differentiation pathways in peritoneal exudate cells from cats with FIP compared to peritoneal cells from healthy cats

From: Characterization of peritoneal cells from cats with experimentally-induced feline infectious peritonitis (FIP) using RNA-seq

Gene symbol Description Log2FC P adjusted
KEGG Th1 polarization
 IFNG Interferon, gamma 6.02974 7.48E−10
 IL12B Interleukin 12B 3.83086 2.91E−06
 IL12RB1 Interleukin 12 receptor, beta 1 3.82454 2.62E−20
 IL12RB2 Interleukin 12 receptor, beta 2 3.22364 3.50E−08
 STAT1 Signal transducer and activator of transcription 1, 91 kDa 2.58559 2.72E−11
 TYK2 Tyrosine kinase 2 2.52411 8.23E−09
 TBX21 T-box 21 2.49393 0.00033
 JAK2 Janus kinase 2 1.93023 4.96E07
 MAML1 Mastermind-like 1 (Drosophila) 1.82799 4.14E06
 RBPJL Recombination signal binding protein for immunoglobulin kappa J region-like 1.67996 0.22008
 RELA v-rel avian reticuloendotheliosis viral 1.48184 0.00019
 STAT4 Signal transducer and activator of transcription 4 1.46177 0.00289
 IFNGR1 Interferon gamma receptor 1 0.46379 0.39809
 DLL1 Delta-like 1 (Drosophila) -2.74765 1.65E −10
 NOTCH3 Notch 3 -4.00499 4.20E −15
KEGG Th2 polarization
 IL6a Interleukin 6 4.86971 0.00071
 IL2RG Interleukin 2 receptor, gamma 4.52368 7.33E−20
 PRDMIa Blimp-1, PR domain containing 1, with ZNF domain 3.77121 5.13E−10
 CD40a TNFSF5, tumor necrosis factor super family 5 3.36350 1.65E−17
 IL4R Interleukin 4 receptor 2.8196 7.44E−13
 BAFFa TNFS13B, tumor necrosis factor super family 13B 1.7417 4.41E−06 b
 GATA3 GATA binding protein 3 1.7299 0.01676
 RBPJL Recombination signal binding protein for immunoglobulin kappa J region-like 1.6799 0.22008
 IL2RA Interleukin 2 receptor, alpha 0.3470 0.67473
 STAT6 Signal transducer and activator of transcription 6, interleukin-4 induced 0.1629 0.75754
IL4 Interleukin 4 0 0.01694
NOTCH2 Notch 2 0.1502 0.58684
 MAML3 Mastermind-like 3 (Drosophila) 0.7689 0.02175
 JAG2 Jagged 2 −2.34773 6.33E −10
  1. Table was produced based on KEGG Th1 and Th2 cell differentiation pathway (KEGG map04658). Genes in italics were significantly up-regulated and Underlined genes were significantly down-regulated (P < 0.05).
  2. aGenes added to KEGG Th2 cell polarization pathway based on FIP literature.
  3. b Slightly below > 2.0 Log2FC but P value highly significant.