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Table 7 Differential expression profile of alternative Fc receptors in peritoneal exudate cells from cats with FIP compared to peritoneal cells from healthy cats

From: Characterization of peritoneal cells from cats with experimentally-induced feline infectious peritonitis (FIP) using RNA-seq

Gene Ligand Cell distribution Effect following binding to antibody Log2FC P adjusted
FcγRIIA (CD32) IgG Macrophages neutrophils eosinophils, DC, platelet Phagocytosis, degranulation eosinophils ND  
FcγRIIB1 (CD32) IgG B cells mast cells No effect on phagocytosis, inhibition of cell activity 1.03 0.011
FcγRIIIA (CD16a) IgG B-cell, NK cells, neutrophils, macrophages, FDC Induction of ADCC, cytokine release by macrophage 2.32 8.20E−10
FcγRIIIB (CD16b) IgG Eosinophils macrophages neutrophils mast cells follicular dendritic cells Induction microbe killing ND  
FcεRI IgE Mast cells, monocytes, eosinophils basophils langerhans cells Degranulation eosinophils, phagocytosis ND  
FcεRII (CD23) IgE B cells, eosinophils. Langerhan cells Allergic sensitization, IgE transport 0.93 0.237
FcαRI (CD89) IgA Monocytes macrophages neutrophils, eosinophils Phagocytosis, microbe killing ND  
Fcα/μR IgA, IgM B cells, mesangial cells, macrophages Endocytosis, induction microbe killing 0.88 0.44
FcRn (FCGRT) IgG Monocytes macrophages dendritic cells epithelial cells endothelial cells Maternal IgG transfer placenta and milk, protects IgG from degradation −0.54 0.200
  1. Genes in italics were significantly up-regulated. Several RNAs were not detected (ND).