|
FcγRIIA (CD32)
|
IgG
|
Macrophages neutrophils eosinophils, DC, platelet
|
Phagocytosis, degranulation eosinophils
|
ND
| |
|
FcγRIIB1 (CD32)
|
IgG
|
B cells mast cells
|
No effect on phagocytosis, inhibition of cell activity
|
1.03
|
0.011
|
|
FcγRIIIA (CD16a)
|
IgG
|
B-cell, NK cells, neutrophils, macrophages, FDC
|
Induction of ADCC, cytokine release by macrophage
|
2.32
|
8.20E−10
|
|
FcγRIIIB (CD16b)
|
IgG
|
Eosinophils macrophages neutrophils mast cells follicular dendritic cells
|
Induction microbe killing
|
ND
| |
|
FcεRI
|
IgE
|
Mast cells, monocytes, eosinophils basophils langerhans cells
|
Degranulation eosinophils, phagocytosis
|
ND
| |
|
FcεRII (CD23)
|
IgE
|
B cells, eosinophils. Langerhan cells
|
Allergic sensitization, IgE transport
|
0.93
|
0.237
|
|
FcαRI (CD89)
|
IgA
|
Monocytes macrophages neutrophils, eosinophils
|
Phagocytosis, microbe killing
|
ND
| |
|
Fcα/μR
|
IgA, IgM
|
B cells, mesangial cells, macrophages
|
Endocytosis, induction microbe killing
|
0.88
|
0.44
|
|
FcRn (FCGRT)
|
IgG
|
Monocytes macrophages dendritic cells epithelial cells endothelial cells
|
Maternal IgG transfer placenta and milk, protects IgG from degradation
|
−0.54
|
0.200
|
