Gene | Ligand | Cell distribution | Effect following binding to antibody | Log2FC | P adjusted |
---|---|---|---|---|---|
FcγRIIA (CD32) | IgG | Macrophages neutrophils eosinophils, DC, platelet | Phagocytosis, degranulation eosinophils | ND |  |
FcγRIIB1 (CD32) | IgG | B cells mast cells | No effect on phagocytosis, inhibition of cell activity | 1.03 | 0.011 |
FcγRIIIA (CD16a) | IgG | B-cell, NK cells, neutrophils, macrophages, FDC | Induction of ADCC, cytokine release by macrophage | 2.32 | 8.20E−10 |
FcγRIIIB (CD16b) | IgG | Eosinophils macrophages neutrophils mast cells follicular dendritic cells | Induction microbe killing | ND |  |
FcεRI | IgE | Mast cells, monocytes, eosinophils basophils langerhans cells | Degranulation eosinophils, phagocytosis | ND |  |
FcεRII (CD23) | IgE | B cells, eosinophils. Langerhan cells | Allergic sensitization, IgE transport | 0.93 | 0.237 |
FcαRI (CD89) | IgA | Monocytes macrophages neutrophils, eosinophils | Phagocytosis, microbe killing | ND |  |
Fcα/μR | IgA, IgM | B cells, mesangial cells, macrophages | Endocytosis, induction microbe killing | 0.88 | 0.44 |
FcRn (FCGRT) | IgG | Monocytes macrophages dendritic cells epithelial cells endothelial cells | Maternal IgG transfer placenta and milk, protects IgG from degradation | −0.54 | 0.200 |